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The role of percutaneous image-guided ablation for lung tumors

  • VASCULAR AND INTERVENTIONAL RADIOLOGY
  • Published:
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Abstract

Surgical resection is the standard treatment for early-stage primary lung cancer and selected cases with pulmonary metastases. However, lung resection may not be possible in patients with compromised pulmonary function, concurrent medical conditions, or previous lung resections. Image-guided ablation has emerged as a less invasive treatment option for unresectable lung tumors that allows for preservation of pulmonary function and promising efficacy. Hereby we describe the indications for and outcomes of image-guided ablation performed for the management of pulmonary malignancies.

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References

  1. Greene FL (2002) The American joint committee on cancer: updating the strategies in cancer staging. Bull Am Coll Surg 87(7):13–15

    Google Scholar 

  2. Kaskowitz L, Graham MV, Emami B et al (1993) Radiation therapy alone for stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys 27(3):517–523

    Article  CAS  PubMed  Google Scholar 

  3. Kupelian PA, Komaki R, Allen P (1996) Prognostic factors in the treatment of node-negative nonsmall cell lung carcinoma with radiotherapy alone. Int J Radiat Oncol Biol Phys 36(3):607–613

    Article  CAS  PubMed  Google Scholar 

  4. Jemal A, Siegel R, Ward E et al (2006) Cancer statistics. CA Cancer J Clin 56(2):106–130

    Article  PubMed  Google Scholar 

  5. Pastorino U (1997) Lung metastasectomy for colorectal cancer. Tumori 83(1 Suppl):S28–30

    CAS  PubMed  Google Scholar 

  6. Ambrogi MC, Fontanini G, Cioni R et al (2006) Biologic effects of radiofrequency thermal ablation on non-small cell lung cancer: results of a pilot study. J Thorac Cardiovasc Surg 131(5):1002–1006

    Article  PubMed  Google Scholar 

  7. Lencioni R, Crocetti L, Cioni R et al (2008) Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study). Lancet Oncol 9(7):621–628

    Article  PubMed  Google Scholar 

  8. Sofocleous CT, May B, Petre EN et al (2011) Pulmonary thermal ablation in patients with prior pneumonectomy. AJR Am J Roentgenol 196(5):W606–W612

    Article  PubMed  Google Scholar 

  9. Hess A, Palussiere J, Goyers JF et al (2011) Pulmonary radiofrequency ablation in patients with a single lung: feasibility, efficacy, and tolerance. Radiol 258(2):635–642

    Article  Google Scholar 

  10. Livraghi T, Solbiati L, Meloni F et al (2003) Percutaneous radiofrequency ablation of liver metastases in potential candidates for resection: the “test-of-time approach”. Cancer 97(12):3027–3035

    Article  PubMed  Google Scholar 

  11. Pua BB, Thornton RH, Solomon SB (2010) Ablation of pulmonary malignancy: current status. J Vasc Intervent Radiol: JVIR 21(8 Suppl):S223–S232

    Article  Google Scholar 

  12. McTaggart RA, Dupuy DE (2007) Thermal ablation of lung tumors. Tech Vasc Intervent Radiol 10(2):102–113

    Article  Google Scholar 

  13. Gomez FM, Palussiere J, Palussiere J, Santos E et al (2009) Radiofrequency thermocoagulation of lung tumours. Where we are, where we are headed. Clinic Trans Oncol 11(1):28–34

    Article  CAS  Google Scholar 

  14. Anderson EM, Lees WR, Gillams AR (2009) Early indicators of treatment success after percutaneous radiofrequency of pulmonary tumors. Cardiovasc Intervent Radiol 32(3):478–483

    Article  PubMed  Google Scholar 

  15. Dequanter D, Lothaire P (2009) Tumour characteristics and therapeutic results after percutaneous radiofrequency ablation of secondary lung neoplasms. Clinic Trans Oncol 11(6):393–395

    Article  Google Scholar 

  16. Ponder E (1962) The coefficient of thermal conductivity of blood and of various tissues. J General Physiol 45:545–551

    Article  CAS  Google Scholar 

  17. Solazzo SA, Liu Z, Lobo SM et al (2005) Radiofrequency ablation: importance of background tissue electrical conductivity—an agar phantom and computer modeling study. Radiology 236(2):495–502

    Article  PubMed  Google Scholar 

  18. Goldberg SN, Hahn PF, Tanabe KK et al (1998) Percutaneous radiofrequency tissue ablation: does perfusion-mediated tissue cooling limit coagulation necrosis? J Vasc Intervent Radiol: JVIR 9(1 Pt 1):101–111

    Article  CAS  Google Scholar 

  19. Knappe V, Mols A (2004) Laser therapy of the lung: biophysical background. Der Radiologe 44(7):677–683

    Article  CAS  PubMed  Google Scholar 

  20. Gage AA, Baust J (1998) Mechanisms of tissue injury in cryosurgery. Cryobiology 37(3):171–186

    Article  CAS  PubMed  Google Scholar 

  21. Hinshaw JL, Lee FT Jr, Laeseke PF et al (2010) Temperature isotherms during pulmonary cryoablation and their correlation with the zone of ablation. J Vasc Intervent Radiol: JVIR 21(9):1424–1428

    Article  Google Scholar 

  22. Hinshaw JL, Littrup PJ, Durick N et al (2010) Optimizing the protocol for pulmonary cryoablation: a comparison of a dual- and triple-freeze protocol. Cardiovasc Intervent Radiol 33(6):1180–1185

    Article  PubMed Central  PubMed  Google Scholar 

  23. Littrup PJ, Mody A, Sparschu R et al (1994) Prostatic cryotherapy: ultrasonographic and pathologic correlation in the canine model. Urology 44(2):175–183 (discussion 183–174)

    Article  CAS  PubMed  Google Scholar 

  24. Belfiore G, Moggio G, Tedeschi E et al (2004) CT-guided radiofrequency ablation: a potential complementary therapy for patients with unresectable primary lung cancer—a preliminary report of 33 patients. AJR Am J Roentgenol 183(4):1003–1011

    Article  PubMed  Google Scholar 

  25. Carrafiello G, Mangini M, Fontana F et al (2012) Radiofrequency ablation for single lung tumours not suitable for surgery: seven years’ experience. Radiol Med 117(8):1320–1332

    Article  CAS  PubMed  Google Scholar 

  26. Liu H, Steinke K (2013) High-powered percutaneous microwave ablation of stage I medically inoperable non-small cell lung cancer: a preliminary study. J Med Imaging Radiat Oncol 57(4):466–474

    Article  CAS  PubMed  Google Scholar 

  27. Herrera LJ, Fernando HC, Perry Y et al (2003) Radiofrequency ablation of pulmonary malignant tumors in nonsurgical candidates. J Thorac Cardiovasc Surg 125(4):929–937

    Article  PubMed  Google Scholar 

  28. de Baere T, Palussiere J, Auperin A et al (2006) Midterm local efficacy and survival after radiofrequency ablation of lung tumors with minimum follow-up of 1 year: prospective evaluation. Radiology 240(2):587–596

    Article  PubMed  Google Scholar 

  29. Gillams AR, Lees WR (2008) Radiofrequency ablation of lung metastases: factors influencing success. Eur Radiol 18(4):672–677

    Article  PubMed  Google Scholar 

  30. Okuma T, Matsuoka T, Yamamoto A et al (2010) Determinants of local progression after computed tomography-guided percutaneous radiofrequency ablation for unresectable lung tumors: 9-year experience in a single institution. Cardiovasc Intervent Radiol 33(4):787–793

    Article  PubMed  Google Scholar 

  31. Kim SR, Han HJ, Park SJ et al (2011) Comparison between surgery and radiofrequency ablation for stage I non-small cell lung cancer. Eur J Radiol 81(2):395–399

    Article  PubMed  Google Scholar 

  32. Zemlyak A, Moore WH, Bilfinger TV (2010) Comparison of survival after sublobar resections and ablative therapies for stage I non-small cell lung cancer. J Am Coll Surg 211(1):68–72

    Article  PubMed  Google Scholar 

  33. Dupuy DE (2013) Treatment of medically inoperable non-small-cell lung cancer with stereotactic body radiation therapy versus image-guided tumor ablation: can interventional radiology compete? J Vasc Interv Radiol 24(8):1139–1145

    Article  PubMed  Google Scholar 

  34. Baumann P, Nyman J, Hoyer M et al (2009) Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy. J Clin Oncol 27(20):3290–3296

    Article  PubMed  Google Scholar 

  35. Fakiris AJ, McGarry RC, Yiannoutsos CT et al (2009) Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study. Int J Radiat Oncol Biol Phys 75(3):677–682

    Article  PubMed  Google Scholar 

  36. Timmerman R, Paulus R, Galvin J et al (2010) Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA 303(11):1070–1076

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  37. Huang L, Han Y, Zhao J et al (2011) Is radiofrequency thermal ablation a safe and effective procedure in the treatment of pulmonary malignancies? Eur J Cardiothorac Surg 39(3):348–351

    Article  PubMed  Google Scholar 

  38. Ridge CA, Silk M, Petre EN et al (2014) Radiofrequency Ablation of T1 Lung carcinoma: comparison of outcomes for first primary, metachronous, and synchronous lung tumors. J Vasc Interv Radiol

  39. Lagerwaard FJ, Haasbeek CJ, Smit EF et al (2008) Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 70(3):685–692

    Article  PubMed  Google Scholar 

  40. Onishi H, Araki T, Shirato H et al (2004) Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer 101(7):1623–1631

    Article  PubMed  Google Scholar 

  41. Dupuy DE, Zagoria RJ, Akerley W et al (2000) Percutaneous radiofrequency ablation of malignancies in the lung. AJR Am J Roentgenol 174(1):57–59

    Article  CAS  PubMed  Google Scholar 

  42. King J, Glenn D, Clark W et al (2004) Percutaneous radiofrequency ablation of pulmonary metastases in patients with colorectal cancer. Br J Surg 91(2):217–223

    Article  CAS  PubMed  Google Scholar 

  43. Steinke K, King J, Glenn DW et al (2004) Percutaneous radiofrequency ablation of lung tumors with expandable needle electrodes: tips from preliminary experience. AJR Am J Roentgenol 183(3):605–611

    Article  PubMed  Google Scholar 

  44. Suh RD, Wallace AB, Sheehan RE et al (2003) Unresectable pulmonary malignancies: CT-guided percutaneous radiofrequency ablation–preliminary results. Radiology 229(3):821–829

    Article  PubMed  Google Scholar 

  45. Dupuy DE, Mayo-Smith WW, Abbott GF, et al. (2002) Clinical applications of radio-frequency tumor ablation in the thorax. Radiographics : a review publication of the Radiological Society of North America, Inc 22 Spec No:S259–S269

  46. Vogl TJ, Naguib NN, Eichler K et al (2008) Volumetric evaluation of liver metastases after thermal ablation: long-term results following MR-guided laser-induced thermotherapy. Radiology 249(3):865–871

    Article  PubMed  Google Scholar 

  47. Yan TD, King J, Sjarif A et al (2007) Treatment failure after percutaneous radiofrequency ablation for nonsurgical candidates with pulmonary metastases from colorectal carcinoma. Ann Surg Oncol 14(5):1718–1726

    Article  PubMed  Google Scholar 

  48. Yamakado K, Hase S, Matsuoka T et al (2007) Radiofrequency ablation for the treatment of unresectable lung metastases in patients with colorectal cancer: a multicenter study in Japan. J Vasc Interv Radiol 18(3):393–398

    Article  PubMed  Google Scholar 

  49. Hiraki T, Gobara H, Iishi T et al (2007) Percutaneous radiofrequency ablation for pulmonary metastases from colorectal cancer: midterm results in 27 patients. J Vasc Interv Radiol 18(10):1264–1269

    Article  PubMed  Google Scholar 

  50. Gillams A, Khan Z, Osborn P et al (2013) Survival after radiofrequency ablation in 122 patients with inoperable colorectal lung metastases. Cardiovasc Intervent Radiol 36(3):724–730

    Article  PubMed  Google Scholar 

  51. Petre EN, Jia X, Thornton RH et al (2013) Treatment of pulmonary colorectal metastases by radiofrequency ablation. Clin Colorectal Cancer 12(1):37–44

    Article  PubMed  Google Scholar 

  52. Yamauchi Y, Izumi Y, Kawamura M et al (2011) Percutaneous cryoablation of pulmonary metastases from colorectal cancer. PLoS One 6(11):e27086

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  53. Vogl TJ, Naguib NN, Gruber-Rouh T et al (2011) Microwave ablation therapy: clinical utility in treatment of pulmonary metastases. Radiol 261(2):643–651

    Article  Google Scholar 

  54. Yan TD, King J, Sjarif A et al (2006) Percutaneous radiofrequency ablation of pulmonary metastases from colorectal carcinoma: prognostic determinants for survival. Ann Surg Oncol 13(11):1529–1537

    Article  PubMed  Google Scholar 

  55. Steinke K, Glenn D, King J et al (2004) Percutaneous imaging-guided radiofrequency ablation in patients with colorectal pulmonary metastases: 1-year follow-up. Ann Surg Oncol 11(2):207–212

    Article  PubMed  Google Scholar 

  56. Schlijper RC, Grutters JP, Houben R et al (2014) What to choose as radical local treatment for lung metastases from colo-rectal cancer: surgery or radiofrequency ablation? Cancer Treat Rev 40(1):60–67

    Article  PubMed  Google Scholar 

  57. Ambrogi MC, Lucchi M, Dini P et al (2006) Percutaneous radiofrequency ablation of lung tumours: results in the mid-term. Eur J Cardio-thorac Surg 30(1):177–183

    Article  Google Scholar 

  58. Pua BB, Solomon SB (2009) Radiofrequency ablation of primary and metastatic lung cancers. Semin Ultrasound CT MR 30(2):113–124

    Article  PubMed  Google Scholar 

  59. Sher DJ, Wee JO, Punglia RS (2011) Cost-effectiveness analysis of stereotactic body radiotherapy and radiofrequency ablation for medically inoperable, early-stage non-small cell lung cancer. Int J Radiat Oncol Biol Phys 81(5):e767–e774

    Article  PubMed  Google Scholar 

  60. Ambrogi MC, Fanucchi O, Lencioni R et al (2006) Pulmonary radiofrequency ablation in a single lung patient. Thorax 61(9):828–829

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  61. Hiraki T, Gobara H, Mimura H et al (2011) Percutaneous radiofrequency ablation of clinical stage I non-small cell lung cancer. J Thorac Cardiovasc Surg 142(1):24–30

    Article  PubMed  Google Scholar 

  62. Ambrogi MC, Fanucchi O, Cioni R et al (2011) Long-term results of radiofrequency ablation treatment of stage I non-small cell lung cancer: a prospective intention-to-treat study. J Thorac Oncol 6(12):2044–2051

    Article  PubMed  Google Scholar 

  63. Lanuti M, Sharma A, Willers H et al (2012) Radiofrequency ablation for stage I non-small cell lung cancer: management of locoregional recurrence. Ann Thorac Surg 93(3):921–927 (discussion 927–988)

    Article  PubMed  Google Scholar 

  64. Lee JM, Jin GY, Goldberg SN et al (2004) Percutaneous radiofrequency ablation for inoperable non-small cell lung cancer and metastases: preliminary report. Radiol 230(1):125–134

    Article  Google Scholar 

  65. Fernando HC, De Hoyos A, Landreneau RJ et al (2005) Radiofrequency ablation for the treatment of non-small cell lung cancer in marginal surgical candidates. J Thorac Cardiovasc Surg 129(3):639–644

    Article  PubMed  Google Scholar 

  66. Simon CJ, Dupuy DE, DiPetrillo TA et al (2007) Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients. Radiology 243(1):268–275

    Article  PubMed  Google Scholar 

  67. Wolf FJ, Grand DJ, Machan JT et al (2008) Microwave ablation of lung malignancies: effectiveness, CT findings, and safety in 50 patients. Radiology 247(3):871–879

    Article  PubMed  Google Scholar 

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Correspondence to Elena N. Petre.

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Petre, E.N., Solomon, S.B. & Sofocleous, C.T. The role of percutaneous image-guided ablation for lung tumors. Radiol med 119, 541–548 (2014). https://doi.org/10.1007/s11547-014-0427-7

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