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Targeted Therapies in the Treatment of Sarcomas

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Abstract

About 50% of sarcomas have specific pathology-defining molecular alterations including mutations, fusion genes, and gene amplifications. Some of these alterations appear to be oncogenic drivers, and a subset can be utilized as targets for standard or experimental molecularly targeted agents in the clinic. In addition, immunotherapies may have a growing role in the treatment of sarcomas in the future.

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  1. Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Anschutz Cancer Pavilion Rm 5310, MS 8111, Aurora, CO, 80045, USA

    Brianna Hoffner, Anthony D. Elias & Victor M. Villalobos

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  1. Brianna Hoffner
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  2. Anthony D. Elias
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Correspondence to Anthony D. Elias.

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Brianna Hoffner, Anthony D. Elias, and Victor M Villalobos declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.

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Hoffner, B., Elias, A.D. & Villalobos, V.M. Targeted Therapies in the Treatment of Sarcomas. Targ Oncol 13, 557–565 (2018). https://doi.org/10.1007/s11523-018-0583-0

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