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Power spectra prognostic aspects of impulsive eye movement traces in superior vestibular neuritis

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Abstract

Since usefulness of power spectra (PS) analysis was demonstrated in many fields of electrophysiology, the aims of the present study were to evaluate differences in frequency domain values of eye velocity traces between a group of 60 healthy subjects (HC) and 35 matched superior vestibular neuritis (VN) patients and to determine prognostic aspects of such values in terms of superior VN recovery. PS calculated on video head impulse test traces was compared between HC and during the acute stage of vertigo (T1) and after 3 months (T2) in superior VN patients. A multiple regression and desirability model between Δ (T2gain − T1gain) vestibulo-ocular reflex (VOR) gain and five prognostic factors were employed. Significant PS differences within the 7.8–16.6 Hz domain were found between superior VN and HC. A significant negative correlation was found between the 7.8–16.6 Hz domain unitary PS value and Δ VOR gain (β = − 0.836). The desirability model depicted a cutoff value of the unitary PS equal to 1.82 in order to obtain a Δ VOR gain rate at least equal to 0.1. Present findings could be a further step for monitoring those superior VN patients with systemic risk factors and high risk of VOR incomplete recovery.

In the top left, healthy control (HC) and superior vestibular neuritis (VN) subjects were screened by means of video head impulse test. In the top right, significant differences in power spectra values were depicted within the 7.8–16.6 Hz domain when comparing the two groups of subjects. In the bottom center, the desirability model depicts a cutoff value of the power spectra equal to 1.82 in order to obtain a Δ vestibulo-ocular reflex gain rate at least equal to 0.1.

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Authors and Affiliations

  1. Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier, 1; E sud Tower, 00133, Rome, Italy

    Alessandro Micarelli, Andrea Viziano & Marco Alessandrini

  2. ITER Center for Balance and Rehabilitation Research, Rome, Italy

    Alessandro Micarelli

  3. Department of Information Engineering, Electronics and Telecommunications, University of Rome “La Sapienza”, Rome, Italy

    Massimo Panella

  4. Department of Biology, University of Rome Tor Vergata, Rome, Italy

    Elisa Micarelli

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  1. Alessandro Micarelli
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  2. Andrea Viziano
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Contributions

Study concept and design: AM, MA, AV, MP, and EM. Acquisition of data: AM, MA, and AV. Analysis or interpretation of data: AM, EM, MP, MA, and AV. Drafting/revising the manuscript: AM, MA, AV, EM, and MP. Critical revision of the manuscript for important intellectual content: MA, AM, AV, MP, and EM.

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Correspondence to Marco Alessandrini.

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The study adhered to the principles of the Declaration of Helsinki, and all the participants provided written informed consent after receiving a detailed explanation of the study, which was approved by the Institutional Ethical Committee of the University of Rome “Tor Vergata” (n.5160/2017).

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The authors declare that they have no conflict of interest.

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Micarelli, A., Viziano, A., Panella, M. et al. Power spectra prognostic aspects of impulsive eye movement traces in superior vestibular neuritis. Med Biol Eng Comput 57, 1617–1627 (2019). https://doi.org/10.1007/s11517-019-01982-3

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