Abstract
Decision-making is one of the cognitive domains in which drug users are commonly impaired. To our knowledge, few studies have investigated the underlying mechanism of risk-taking behavior among individuals with methamphetamine use disorder (MUD) using a computational approach. Ninety-six right-handed male participants (63 individuals with MUD who were currently abstinent and 33 healthy controls) were included in Experiment 1, and 94 right-handed male participants (63 individuals with MUD who were currently abstinent and 31 healthy controls) were included in Experiment 2. To investigate whether individuals with MUD exhibit different risk-taking behavior from healthy controls and understand the possible underlying psychological processes, we used the Balloon Analogue Risk Task (BART) with and without methamphetamine-related pictures and the method of computational modeling. After individuals with MUD completed the BART, a 5-min video of methamphetamine use was displayed, and individuals with MUD then rated their subjective craving using a visual analogue scale. Individuals with MUD displayed higher risk-taking behavior than healthy controls when participants were exposed to methamphetamine-related pictures. The results of computational modeling revealed that the risk-taking propensity parameter was significantly higher in individuals with MUD than in healthy controls. The craving scores were positively correlated with the risk-taking propensity parameter and the updating coefficient when individuals with MUD were exposed to methamphetamine-related pictures. Higher risk taking in individuals with MUD could be explained by differences in the risk-taking propensity parameter, which reflects how participants evaluate the outcomes. These findings can be used to guide future work in targeting the evaluation process among people with MUD.
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We thank Ming-Hui Li, Di Zhao, Qian Zhuang, Bin Zhan, Lanjun Zhou, and Yan Zeng for helps in collecting the data.
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This work was supported by the National Natural Science Foundation of China (no. 92046006; 31671166), Young Elite Scientists Sponsorship Program by CAST (no. YESS20160143), and Lingang Laboratory grant no. LG-QS-202203–10. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Sui, XY., Zhang, M., Yuan, TF. et al. Impaired Outcome Evaluation During Risky Decision-Making in Individuals with Methamphetamine Use Disorder. Int J Ment Health Addiction 22, 299–318 (2024). https://doi.org/10.1007/s11469-022-00873-3
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DOI: https://doi.org/10.1007/s11469-022-00873-3