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Development of Glucose Sensor Using Gold Nanoparticles and Glucose-Oxidase Functionalized Tapered Fiber Structure

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Abstract

Diabetes mellitus is a common health issue in human beings. It is very important to develop a highly selective and sensitive biosensor for the detection of glucose concentration in the human body. The proposed sensor is based on localized surface plasmon resonance (LSPR) technique. An optical tapered fiber structure is used to develop the proposed sensor. Gold nanoparticles (AuNPs) are used to increase the sensitivity of the sensor probe. AuNPs of size ~ 10 nm is synthesized for this purpose. The characterization of AuNPs was performed with the UV-vis spectroscopy, transmission electron microscope (TEM), and scanning electron microscope (SEM). Further, glucose oxidase enzyme is used to increase the selectivity of the sensor. The selectivity of sensor is tested with different analytes such as cholesterol, urea, L-cysteine, ascorbic acid, and galactose that are generally found in the serum.

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Funding

This work was supported by the National Natural Science Foundation of China (No.61501214), National Key R&D Program of China (2016YFB0402105), the Belt and Road Special Project approved by Shandong Province for Introduction of Foreign Experts in 2018, and Liaocheng University, China (31805180301, 31805180326).

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Authors and Affiliations

  1. Shandong Key Laboratory of Optical Communication Science and Technology, School of Physics Science and Information Technology, Liaocheng University, 252000, Liaocheng, Shandong, China

    Qingshan Yang, Xia Zhang, Santosh Kumar, Bingyuan Zhang & Chenglin Bai

  2. School of Agriculture Science, Liaocheng University, 252000, Liaocheng, Shandong, China

    Ragini Singh

  3. School of Materials Science and Engineering, Liaocheng University, 252000, Liaocheng, Shandong, China

    Xipeng Pu

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  1. Qingshan Yang
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  2. Xia Zhang
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  3. Santosh Kumar
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  4. Ragini Singh
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  5. Bingyuan Zhang
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  6. Chenglin Bai
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  7. Xipeng Pu
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Correspondence to Xia Zhang or Santosh Kumar.

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Yang, Q., Zhang, X., Kumar, S. et al. Development of Glucose Sensor Using Gold Nanoparticles and Glucose-Oxidase Functionalized Tapered Fiber Structure. Plasmonics 15, 841–848 (2020). https://doi.org/10.1007/s11468-019-01104-7

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  • DOI: https://doi.org/10.1007/s11468-019-01104-7

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