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Characterization of cocrystals formed by grinding amino acids through terahertz time-domain spectroscopy

  • Article
  • Chemical Engineering
  • Published:
Chinese Science Bulletin

Abstract

In this paper, we used terahertz time-domain spectroscopy (THz-TDS) over a range of 0.3–2.5 THz to investigate the formation of solid-state cocrystals of amino acids, formed by grinding mixtures of two different kinds of amino acids. For comparison, we prepared dual-layer samples, combined by pressing two single-component pellets together without grinding. In the ground-mixture samples, some extra absorption peaks appeared, different from the characteristic peaks of the pure components, but these peaks did not appear in the dual-layer samples. Thus, these extra absorption peaks in the THz range are unique features of cocrystals. From our results, we believe that THz-TDS is a promising technique to characterize cocrystals.

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Aknowledgments

This work was supported by the National Natural Science Foundation of China (61302007 and 60977065) and the Fundamental Research Funds for the Central Universities (FRF-SD-12-016A). Thanks to Prof. Michael Johnston and Dr. Katherine Dunn of Oxford Terahertz Photonics Group for their cooperation and support in experiments.

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Authors and Affiliations

  1. Department of Instrumentation Science, School of Automation and Electrical Engineering, University of Science and Technology Beijing, Beijing, 100083, China

    Xiaoyan Zhao, Haixia Su, Zhaohui Zhang, Zhi Li, Han Zhang & Tianyao Zhang

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  1. Xiaoyan Zhao
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  2. Haixia Su
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  3. Zhaohui Zhang
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  4. Zhi Li
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  5. Han Zhang
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  6. Tianyao Zhang
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Correspondence to Xiaoyan Zhao.

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Zhao, X., Su, H., Zhang, Z. et al. Characterization of cocrystals formed by grinding amino acids through terahertz time-domain spectroscopy. Chin. Sci. Bull. 59, 2987–2993 (2014). https://doi.org/10.1007/s11434-014-0432-1

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  • DOI: https://doi.org/10.1007/s11434-014-0432-1

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