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Construction of bio-functional Mg/HA composite layered coating for orthopedic application

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Abstract

Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and HA composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The HA transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/HA coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/HA coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/HA coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/HA composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. School of Materials Science and Engineering, Dongguan University of Technology, Dongguan, 523808, China

    Peng Wan

  2. Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China

    Peng Wan & Ke Yang

  3. School of Materials Science and Engineering, Central South University, Changsha, 410083, China

    XuDong Yan & MingChun Zhao

  4. Research Center of Medical Sciences, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China

    Mei Li & Yu Zhang

Authors
  1. Peng Wan
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  2. XuDong Yan
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  3. Mei Li
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  4. MingChun Zhao
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  5. Yu Zhang
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  6. Ke Yang
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Corresponding authors

Correspondence to Peng Wan or Ke Yang.

Additional information

This work was supported by the National Natural Science Foundation of China (Grant No. 31500777), the Research Start-up Funds of DGUT (Grant No. GC300501-082), and the Characteristic Innovation Project of University in Guangdong (Grant No. 2020KTSCX148).

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Wan, P., Yan, X., Li, M. et al. Construction of bio-functional Mg/HA composite layered coating for orthopedic application. Sci. China Technol. Sci. 64, 2541–2550 (2021). https://doi.org/10.1007/s11431-020-1762-3

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  • DOI: https://doi.org/10.1007/s11431-020-1762-3

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