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The genome-wide molecular regulation of mouse gastrulation embryo

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Abstract

The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body plan is established through a coordinated morphogenetic process and the delineation of tissue lineages that are driven by the activity of the genome. To explore the molecular mechanisms, in a comprehensive context, it is imperative to glean an understanding of the region- and population-specific genetic activity underpinning this fundamental developmental process. In this review, we outline the recent progresses and the future directions in studies of genome activity for the regulation of mouse embryogenesis at gastrulation.

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Acknowledgements

We apologized to authors whose works have not been cited here because of space limitation. This work was supported by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (XDA01010201), National Key Basic Research and Development Program of China (2014CB964804, 2015CB964500), and National Natural Science Foundation of China (31430058, 31571513, 31630043, 91519314).

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  1. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

    Guangdun Peng & Naihe Jing

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  1. Guangdun Peng
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  2. Naihe Jing
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Correspondence to Guangdun Peng or Naihe Jing.

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Peng, G., Jing, N. The genome-wide molecular regulation of mouse gastrulation embryo. Sci. China Life Sci. 60, 363–369 (2017). https://doi.org/10.1007/s11427-016-0285-3

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