Abstract
A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic scaffolds. Structurally diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results (up to 99:1 e.r., >95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(III) complexes.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (92156022), the Anhui Provincial Natural Science Funds (1908085J07, 1908085QB79, 2308085MB44, 2308085QB44), and the Shen-Nong Scholar Program of Anhui Agricultural University.
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Supporting information The supporting information is available online at chem.scichina.com and link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.
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Sequential Enantioselective Ugi-4CR/post-Ugi Transformation Strategy: A Precise Construction of Structurally Diverse Azaspiro Polycyclic Scaffolds
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Wu, XB., Shi, JX., Ou, YM. et al. Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy: a precise construction of structurally diverse azaspiro polycyclic scaffolds. Sci. China Chem. 67, 576–586 (2024). https://doi.org/10.1007/s11426-023-1782-9
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DOI: https://doi.org/10.1007/s11426-023-1782-9