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Se-sensitized NIR hot band absorption photosensitizer for anti-Stokes excitation deep photodynamic therapy

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Abstract

Conventional anti-Stokes materials-involved deep photodynamic therapy (dPDT) requires much high-intensity irradiance due to low photosensitization efficiency. Herein, we proposed a “booster effector” approach to construct highly efficient hot band absorption phototherapeutics for low/biosafety power anti-Stokes light-triggered dPDT. Se, as “booster effector”, was introduced into hot band absorption luminophores (HBAs), which not only significantly facilitated intersystem crossing, but also simultaneously enhanced hot band excitation efficiency at v808, as a result successfully enabling excellent photogenerated singlet oxygen capability of HBAs under ultra-low power anti-Stokes excitation (10 mW cm−2in vitro). As far as we know, such low laser power-initiated photosensitization activity has never been reported in the existing anti-Stokes material systems. Importantly, FUC-SeME can self-assemble into uniform nanospheres in water, greatly boosting cellular uptake (>25-fold larger than FUC-Se), and achieve superior cancer-killing effect (808 nm, 10 mW cm−2, 5 min, the half-maximal inhibitory concentration IC50 = 1.36 µM). After further PEGylation with folate-attached polymer, the resultant FUC-SeME@FA can effectively enrich at the tumor (signal-to-background ratio, 10). Under safety irradiation (330 mW cm−2), FUC-SeME@FA effectively inhibits deep-seated tumor progression (the tumor growth inhibition rate, 84%). This work provides a successful paradigm, possibly being more clinically beneficial than conventional anti-Stokes materials.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22090011) and the NSFC-Liaoning United Fund (U1908202).

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Authors and Affiliations

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China

    Dandan Ma, Hui Bian, Saran Long, Ruisong Tian, Haoying Ge, Mingle Li, Jianjun Du, Jiangli Fan & Xiaojun Peng

  2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China

    Yukui Zhang

  3. Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, China

    Panwang Zhou & Yingnan Wu

  4. Shenzhen Research Institute, Dalian University of Technology, Shenzhen, 518057, China

    Saran Long, Jianjun Du, Jiangli Fan & Xiaojun Peng

  5. Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea

    Mingle Li

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  1. Dandan Ma
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  2. Hui Bian
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  3. Saran Long
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  10. Jiangli Fan
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  11. Yukui Zhang
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  12. Xiaojun Peng
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Correspondence to Xiaojun Peng.

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The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Ma, D., Bian, H., Long, S. et al. Se-sensitized NIR hot band absorption photosensitizer for anti-Stokes excitation deep photodynamic therapy. Sci. China Chem. 65, 563–573 (2022). https://doi.org/10.1007/s11426-021-1179-7

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  • DOI: https://doi.org/10.1007/s11426-021-1179-7

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