Abstract
Functionalized bisboryl compounds have recently emerged as a new class of synthetically useful building blocks in organic synthesis. Herein, we report an efficient strategy to synthesize β-geminal-diboryl ketones enabled by a Cu/Pd-catalyzed borocarbonylative trifunctionalization of readily available alkynes and allenes. This reaction promises to be a useful method for the synthesis of functionalized β-geminal-diboryl ketones with broad functional group tolerance. Mechanistic studies suggest that the reaction proceeds through borocarbonylation/hydroboration cascade of both alkynes and allenes.
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Acknowledgements
This work was supported by the Chinese Scholarship Council (CSC). We also thank the analytical team of LIKAT for their very kind support.
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Yuan, Y., Wu, FP., Spannenberg, A. et al. Cu/Pd-catalyzed borocarbonylative trifunctionalization of alkynes and allenes: synthesis of β-geminal-diboryl ketones. Sci. China Chem. 64, 2142–2153 (2021). https://doi.org/10.1007/s11426-021-1054-4
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DOI: https://doi.org/10.1007/s11426-021-1054-4