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Age at menarche and age at natural menopause in East Asian women: a genome-wide association study

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A Correction to this article was published on 30 January 2018

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Abstract

Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high heritability. Abnormal timing of menarche or menopause is associated with a reduced span of fertility and risk for several age-related diseases including breast, endometrial and ovarian cancer, cardiovascular disease, and osteoporosis. To identify novel genetic loci for AM or ANM in East Asian women and to replicate previously identified loci primarily in women of European ancestry by genome-wide association studies (GWASs), we conducted a two-stage GWAS. Stage I aimed to discover promising novel AM and ANM loci using GWAS data of 8073 women from Shanghai, China. The Stage II replication study used the data from another Chinese GWAS (n = 1230 for AM and n = 1458 for ANM), a Korean GWAS (n = 4215 for AM and n = 1739 for ANM), and de novo genotyping of 2877 additional Chinese women. Previous GWAS-identified loci for AM and ANM were also evaluated. We identified two suggestive menarcheal age loci tagged by rs79195475 at 10q21.3 (beta = −0.118 years, P = 3.4 × 10−6) and rs1023935 at 4p15.1 (beta = −0.145 years, P = 4.9 × 10−6) and one menopausal age locus tagged by rs3818134 at 22q12.2 (beta = −0.276 years, P = 8.8 × 10−6). These suggestive loci warrant a further validation in independent populations. Although limited by low statistical power, we replicated 19 of the 98 menarche loci and 5 of the 20 menopause loci previously identified in women of European ancestry in East Asian women, suggesting a shared genetic architecture for these two traits across populations.

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Change history

  • 30 January 2018

    The original version of this article unfortunately contained a mistake.

References

  • Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu X-O, Yuan J-M, Zheng W, Dawsey SM, Dong LM et al (2010) A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet 42:764–767. doi:10.1038/ng.649

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M (2011) Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep 12:421–427. doi:10.1038/embor.2011.50

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Anderson CA, Zhu G, Falchi M, van den Berg SM, Treloar SA, Spector TD, Martin NG, Boomsma DI, Visscher PM, Montgomery GW (2008) A genome-wide linkage scan for age at menarche in three populations of European descent. J Clin Endocrinol Metab 93:3965–3970. doi:10.1210/jc.2007-2568

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carty CL, Spencer KL, Setiawan VW, Fernandez-Rhodes L, Malinowski J, Buyske S, Young A, Jorgensen NW, Cheng I, Carlson CS et al (2013) Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study. Hum Reprod Oxf Engl 28:1695–1706. doi:10.1093/humrep/det071

    Article  Google Scholar 

  • Chen CTL, Fernández-Rhodes L, Brzyski RG, Carlson CS, Chen Z, Heiss G, North KE, Woods NF, Rajkovic A, Kooperberg C et al (2012) Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women’s Health Initiative SHARe Study. Hum Mol Genet 21:1419–1432. doi:10.1093/hmg/ddr570

    Article  CAS  PubMed  Google Scholar 

  • Chen CTL, Liu C-T, Chen GK, Andrews JS, Arnold AM, Dreyfus J, Franceschini N, Garcia ME, Kerr KF, Li G et al (2014) Meta-analysis of loci associated with age at natural menopause in African-American women. Hum Mol Genet 23:3327–3342. doi:10.1093/hmg/ddu041

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban H-J, Yoon D, Lee MH, Kim D-J, Park M et al (2009) A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41:527–534. doi:10.1038/ng.357

    Article  CAS  PubMed  Google Scholar 

  • Cramer DW (2012) The epidemiology of endometrial and ovarian cancer. Hematol Oncol Clin North Am 26:1–12. doi:10.1016/j.hoc.2011.10.009

    Article  PubMed  Google Scholar 

  • Cui R, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Kondo T, Watanabe Y, Koizumi A, Inaba Y et al (2006) Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: the JACC study. J Epidemiol Jpn Epidemiol Assoc 16:177–184

    Article  Google Scholar 

  • De Bruin JP, Bovenhuis H, van Noord PA, Pearson PL, van Arendonk JA, te Velde ER, Kuurman WW, Dorland M (2001) The role of genetic factors in age at natural menopause. Hum Reprod Oxf Engl 16:2014–2018

    Article  Google Scholar 

  • Delahanty RJ, Beeghly-Fadiel A, Long JR, Gao YT, Lu W, Xiang YB, Zheng Y, Ji BT, Wen WQ, Cai QY et al (2013) Evaluation of GWAS-identified genetic variants for age at menarche among Chinese women. Hum Reprod Oxf Engl 28:1135–1143. doi:10.1093/humrep/det011

    Article  CAS  Google Scholar 

  • Demerath EW, Liu C-T, Franceschini N, Chen G, Palmer JR, Smith EN, Chen CTL, Ambrosone CB, Arnold AM, Bandera EV et al (2013) Genome-wide association study of age at menarche in African-American women. Hum Mol Genet 22:3329–3346. doi:10.1093/hmg/ddt181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL et al (2010) Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet 42:1077–1085. doi:10.1038/ng.714

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI (2009) Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. Nat Genet 41:724–728. doi:10.1038/ng.385

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hinds L, Price J (2010) Menopause, hormone replacement and gynaecological cancers. Menopause Int 16:89–93. doi:10.1258/mi.2010.010018

    PubMed  Google Scholar 

  • Howie BN, Donnelly P, Marchini J (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 5:e1000529. doi:10.1371/journal.pgen.1000529

    Article  PubMed  PubMed Central  Google Scholar 

  • Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I et al (2006) SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. Neuron 50:261–275. doi:10.1016/j.neuron.2006.03.018

    Article  CAS  PubMed  Google Scholar 

  • Jia W-H, Zhang B, Matsuo K, Shin A, Xiang Y-B, Jee SH, Kim D-H, Ren Z, Cai Q, Long J et al (2013) Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Nat Genet 45:191–196. doi:10.1038/ng.2505

    Article  CAS  PubMed  Google Scholar 

  • Kim H, Lee J-Y, Sung H, Choi J-Y, Park SK, Lee K-M, Kim YJ, Go MJ, Li L, Cho YS et al (2012) A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. Breast Cancer Res BCR 14:R56. doi:10.1186/bcr3158

    Article  CAS  PubMed  Google Scholar 

  • Li Y, Willer C, Sanna S, Abecasis G (2009) Genotype imputation. Annu Rev Genomics Hum Genet 10:387–406. doi:10.1146/annurev.genom.9.081307.164242

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR (2010) MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34:816–834. doi:10.1002/gepi.20533

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu Y-Z, Guo Y-F, Wang L, Tan L-J, Liu X-G, Pei Y-F, Yan H, Xiong D-H, Deng F-Y, Yu N et al (2009) Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. PLoS Genet 5:e1000420. doi:10.1371/journal.pgen.1000420

    Article  PubMed  PubMed Central  Google Scholar 

  • Long J, Zheng W, Xiang Y-B, Lose F, Thompson D, Tomlinson I, Yu H, Wentzensen N, Lambrechts D, Dörk T et al (2012) Genome-wide association study identifies a possible susceptibility locus for endometrial cancer. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 21:980–987. doi:10.1158/1055-9965.EPI-11-1160

    Article  CAS  Google Scholar 

  • Marchini J, Howie B, Myers S, McVean G, Donnelly P (2007) A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 39:906–913. doi:10.1038/ng2088

    Article  CAS  PubMed  Google Scholar 

  • Martinez-Sanz J, Kateb F, Assairi L, Blouquit Y, Bodenhausen G, Abergel D, Mouawad L, Craescu CT (2010) Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex. J Mol Biol 395:191–204. doi:10.1016/j.jmb.2009.10.041

    Article  CAS  PubMed  Google Scholar 

  • Morris DH, Jones ME, Schoemaker MJ, Ashworth A, Swerdlow AJ (2011) Familial concordance for age at natural menopause: results from the Breakthrough Generations Study. Menopause N Y N 18:956–961. doi:10.1097/gme.0b013e31820ed6d2

    Article  Google Scholar 

  • Murabito JM, Yang Q, Fox C, Wilson PWF, Cupples LA (2005) Heritability of age at natural menopause in the Framingham Heart Study. J Clin Endocrinol Metab 90:3427–3430. doi:10.1210/jc.2005-0181

    Article  CAS  PubMed  Google Scholar 

  • Ong KK, Elks CE, Li S, Zhao JH, Luan J, Andersen LB, Bingham SA, Brage S, Smith GD, Ekelund U et al (2009) Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet 41:729–733. doi:10.1038/ng.382

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Parker SE, Troisi R, Wise LA, Palmer JR, Titus-Ernstoff L, Strohsnitter WC, Hatch EE (2014) Menarche, menopause, years of menstruation, and the incidence of osteoporosis: the influence of prenatal exposure to diethylstilbestrol. J Clin Endocrinol Metab 99:594–601. doi:10.1210/jc.2013-2954

    Article  CAS  PubMed  Google Scholar 

  • Perry JRB, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E et al (2009) Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet 41:648–650. doi:10.1038/ng.386

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G et al (2014) Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 514:92–97. doi:10.1038/nature13545

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M et al (2010) A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 42:224–228. doi:10.1038/ng.522

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pyun J-A, Kim S, Cho NH, Koh I, Lee J-Y, Shin C, Kwack K (2014) Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population. Menopause N Y N 21:522–529. doi:10.1097/GME.0b013e3182a433f7

    Article  Google Scholar 

  • Qiu C, Chen H, Wen J, Zhu P, Lin F, Huang B, Wu P, Lin Q, Lin Y, Rao H et al (2013) Associations between age at menarche and menopause with cardiovascular disease, diabetes, and osteoporosis in Chinese women. J Clin Endocrinol Metab 98:1612–1621. doi:10.1210/jc.2012-2919

    Article  CAS  PubMed  Google Scholar 

  • Sharma K (2002) Genetic basis of human female pelvic morphology: a twin study. Am J Phys Anthropol 117:327–333. doi:10.1002/ajpa.10055

    Article  PubMed  Google Scholar 

  • Shen C, Delahanty RJ, Gao Y-T, Lu W, Xiang Y-B, Zheng Y, Cai Q, Zheng W, Shu X-O, Long J (2013) Evaluating GWAS-identified SNPs for age at natural menopause among Chinese women. PloS One 8:e58766. doi:10.1371/journal.pone.0058766

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shu XO, Long J, Cai Q, Qi L, Xiang Y-B, Cho YS, Tai ES, Li X, Lin X, Chow W-H et al (2010) Identification of new genetic risk variants for type 2 diabetes. PLoS Genet 6:e1001127. doi:10.1371/journal.pgen.1001127

    Article  PubMed  PubMed Central  Google Scholar 

  • Spencer KL, Malinowski J, Carty CL, Franceschini N, Fernández-Rhodes L, Young A, Cheng I, Ritchie MD, Haiman CA, Wilkens L et al (2013) Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. PloS One 8:e55258. doi:10.1371/journal.pone.0055258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stolk L, Zhai G, van Meurs JBJ, Verbiest MMPJ, Visser JA, Estrada K, Rivadeneira F, Williams FM, Cherkas L, Deloukas P et al (2009) Loci at chromosomes 13, 19 and 20 influence age at natural menopause. Nat Genet 41:645–647. doi:10.1038/ng.387

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F et al (2012) Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet 44:260–268. doi:10.1038/ng.1051

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sulem P, Gudbjartsson DF, Rafnar T, Holm H, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Alexandersen P, Feenstra B, Boyd HA et al (2009) Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. Nat Genet 41:734–738. doi:10.1038/ng.383

    Article  CAS  PubMed  Google Scholar 

  • Tanikawa C, Okada Y, Takahashi A, Oda K, Kamatani N, Kubo M, Nakamura Y, Matsuda K (2013) Genome wide association study of age at menarche in the Japanese population. PloS One 8:e63821. doi:10.1371/journal.pone.0063821

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van Hengel J, Calore M, Bauce B, Dazzo E, Mazzotti E, De Bortoli M, Lorenzon A, Li Mura IEA, Beffagna G, Rigato I et al (2013) Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Eur Heart J 34:201–210. doi:10.1093/eurheartj/ehs373

    Article  PubMed  Google Scholar 

  • Velie EM, Nechuta S, Osuch JR (2005) Lifetime reproductive and anthropometric risk factors for breast cancer in postmenopausal women. Breast Dis 24:17–35

    Article  PubMed  Google Scholar 

  • Vogel VG (2008) Epidemiology, genetics, and risk evaluation of postmenopausal women at risk of breast cancer. Menopause N Y N 15:782–789. doi:10.1097/gme.0b013e3181788d88

    Article  Google Scholar 

  • Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang J-Y, Dorajoo R, Li H, Tsai F-J, Yang X et al (2014) Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet 23:5492–5504. doi:10.1093/hmg/ddu248

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Willer CJ, Li Y, Abecasis GR (2010) METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26:2190–2191. doi:10.1093/bioinformatics/btq340

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ye X, Yu Z, Li H, Franco OH, Liu Y, Lin X (2007) Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J Am Coll Cardiol 49:1798–1805. doi:10.1016/j.jacc.2007.01.065

    Article  CAS  PubMed  Google Scholar 

  • Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA, Boerwinkle E (2013) Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. Genet Epidemiol 37:840–845. doi:10.1002/gepi.21752

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang B, Jia W-H, Matsuda K, Kweon S-S, Matsuo K, Xiang Y-B, Shin A, Jee SH, Kim D-H, Cai Q et al (2014) Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Nat Genet 46:533–542. doi:10.1038/ng.2985

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zheng W, Chow W-H, Yang G, Jin F, Rothman N, Blair A, Li H-L, Wen W, Ji B-T, Li Q et al (2005) The Shanghai Women’s Health Study: rationale, study design, and baseline characteristics. Am J Epidemiol 162:1123–1131. doi:10.1093/aje/kwi322

    Article  PubMed  Google Scholar 

  • Zheng W, Long J, Gao Y-T, Li C, Zheng Y, Xiang Y-B, Wen W, Levy S, Deming SL, Haines JL et al (2009) Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet 41:324–328. doi:10.1038/ng.318

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

This study was supported, in part, by grants from the US National Institutes of Health (grants R01CA124558, R01CA090899, R01CA070867; R01CA064277 and R01CA092585, R01CA118229, R01CA122756, R01CA137013, R01CA148667), Ingram professorship funds, and Allen Foundation funds at Vanderbilt Epidemiology Center and Division of Epidemiology; SeBCS was supported by the Basic Research Laboratory (BRL) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2011-0001564). NHAPC was supported by research grants including the National Basic Research Program of China (2012CB524905 and 2011CB504002), Knowledge Innovation Program (KSCX2-EW-R-10), the National Natural Science Foundation of China (81321062, 81170734, 81471013, 81200581, 81202272), and the Knowledge Innovation Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (2013KIP107 and 2014KIP107). The authors wish to thank Jing He, Hui Cai, Gong Yang, Jie Wu, and Regina Courtney for their contributions to this project, as well as Nan Kennedy for editing and preparing the manuscript. We also thank the research staff of the Shanghai Breast Cancer Genetics Study, Shanghai Endometrial Cancer Genetics Study, the Shanghai Diabetes Genetics Study, the Shanghai Colorectal Cancer Study, the Nutrition and Health of Aging Population in China study, and the Seoul Breast Cancer Study. In addition, sample preparation and GWAS genotyping assays at Vanderbilt were conducted at the Survey and Biospecimen Shared Resources and the Vanderbilt Microarray Shared Resource, which are supported in part by the Vanderbilt-Ingram Cancer Center (P30CA068485).

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Authors and Affiliations

  1. Department of Medicine, Vanderbilt Epidemiology Center and Division of Epidemiology, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, IMPH, Nashville, Tennessee, 37203, USA

    Jiajun Shi, Ben Zhang, Jirong Long, Wanqing Wen, Qiuyin Cai & Xiao-Ou Shu

  2. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

    Ji-Yeob Choi, Daehee Kang, Sue K. Park & Seokang Chung

  3. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea

    Ji-Yeob Choi, Daehee Kang & Sue K. Park

  4. Cancer Research Institute, Seoul National University, Seoul, Korea

    Ji-Yeob Choi, Daehee Kang & Sue K. Park

  5. Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Yu-Tang Gao & Yong-Bing Xiang

  6. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China

    Huaixing Li, Xingwang Ye, Yiqin Wang & Xu Lin

  7. Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

    Wei Lu & Ying Zheng

  8. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea

    Dong-Young Noh

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  1. Jiajun Shi
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Correspondence to Xiao-Ou Shu.

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The authors have no conflict of interest to declare. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or any other funding agency.

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Written informed consent was obtained from all participants, and the study protocols were approved by the institutional review boards of all institutions involved in the study.

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A correction to this article is available online at https://doi.org/10.1007/s11357-018-0007-1.

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Table S1

Genome-wide association-identified suggestive SNPs for age at menarche in East Asian women. (DOCX 28 kb)

Table S2

Genome-wide association-identified suggestive SNPs for age at natural menopause in East Asian women. (DOCX 27 kb)

Table S3

Evaluation of GWAS-identified single nucleotide polymorphisms for age at menarche in East Asian women. (DOCX 178 KB)

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Shi, J., Zhang, B., Choi, JY. et al. Age at menarche and age at natural menopause in East Asian women: a genome-wide association study. AGE 38, 513–523 (2016). https://doi.org/10.1007/s11357-016-9939-5

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