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A preliminary study on the pathology and molecular mechanism of fumonisin B1 nephrotoxicity in young quails

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Abstract

Fumonisin B1 (FB1) is a widely present mycotoxin that accumulates in biological systems and poses a health risk to animals. However, few studies have reported the molecular mechanism by which FB1 induces nephrotoxicity. The aim of this study was to assess the extent of nephrotoxicity during FB1 exposure and the possible molecular mechanisms behind it. Therefore, 180 young quails were equally divided into two groups. The control group was fed typical quail food, while the experimental group was fed quail food containing 30 mg·kg−1 FB1. Various parameters were assessed, which included histopathological, ultrastructural changes, levels of biochemical parameters, oxidative indicators, inflammatory factors, possible target organelles mitochondrial and endoplasmic reticulum (ER)-related factors, nuclear xenobiotic receptors (NXR) response, and cytochrome P450 system (CYP450s)-related factors in the kidneys on days 14, 28, and 42. The results showed that FB1 can induce oxidative stress through NXR response and disorder of the CYP450s system, leading to mitochondrial dysfunction and ER stress, promoting the expression of inflammatory factors (including IL-1β, IL-6, and IL-8) and causing kidney damage. This study elucidated the possible molecular mechanism by which FB1 induces nephrotoxicity in young quails.

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Funding

This work was supported by Guangdong Basic and Applied Basic Research Fundation (2022B1515130003).

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Authors and Affiliations

  1. College of Life Science and Engineering, Foshan University, Foshan, Guangdong, 528231, People’s Republic of China

    Jinhong Li, Mingzhan Zhu, Runxi Xian, Siqiu Chen, Qian Zang, Huquan Zhu & Changyu Cao

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  1. Jinhong Li
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Contributions

Project administration, investigation, material preparation, data collection, and analysis were performed by JL. The first draft of the manuscript was written by JL. MZ, SC, QZ, HZ, and RX revised the manuscript. CC contributed to the study conception and design. All other authors have read the manuscript and have agreed to submit it in its current form for consideration for publication in the journal.

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Correspondence to Changyu Cao.

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All animal studies and experimental design were approved by the Institutional Animal Care and Use Ethics Committee of the Foshan University (FOSU2022023).

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Li, J., Zhu, M., Xian, R. et al. A preliminary study on the pathology and molecular mechanism of fumonisin B1 nephrotoxicity in young quails. Environ Sci Pollut Res 30, 114438–114451 (2023). https://doi.org/10.1007/s11356-023-30291-4

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