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Research advances in identification procedures of endocrine disrupting chemicals

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Abstract

Endocrine disrupting chemicals (EDCs) are increasingly concerned substance endangering human health and environment. However, there is no unified standard for identifying chemicals as EDCs, which is also controversial internationally. In this review, the procedures for EDC identification in different organizations/countries were described. Importantly, three aspects to be considered in identifying chemical substances as EDCs were summarized, which were mechanistic data, animal experiments, and epidemiological information. The relationships between them were also discussed. To elaborate more clearly on these three aspects of evidence, scientific data on some chemicals including bisphenol A, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane and perchlorate were collected and evaluated. Altogether, the above three chemicals were assessed for interfering with hormones and elaborated their health hazards from macroscopic to microscopic. This review is helpful for standardizing the identification procedure of EDCs.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 82273594, 82073512, and 81773384).

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  1. Xing Guo and Bing Liu contributed equally to this work.

Authors and Affiliations

  1. College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of China

    Xing Guo, Bing Liu, Haohao Liu, Xingde Du, Shumeng Yuan, Bingyu Zhang, Yongshui Wang & Huizhen Zhang

  2. Department of Chemistry and Biochemistry, St Mary’s University, San Antonio, TX, USA

    Xinghai Chen

  3. College of Nursing, Jining Medical University, Jining, Shandong, People’s Republic of China

    Wenjun Wang

  4. College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, 450001, People’s Republic of China

    Hongxiang Guo

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  1. Xing Guo
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Contributions

Huizhen Zhang: conceptualization, writing—review and editing, supervision, and funding acquisition. Xing Guo: conceptualization, methodology, software, writing—original draft preparation, and visualization. Bing Liu: conceptualization, methodology, software, writing—original draft preparation, and visualization. Haohao Liu: software and writing—review and editing. Xingde Du: methodology, writing—review and editing, and visualization. Xinghai Chen: writing—review. Wenjun Wang: writing—review. Shumeng Yuan: software. Bingyu Zhang: software. Yongshui Wang: software. Hongxiang Guo: conceptualization and writing—review and editing.

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Correspondence to Huizhen Zhang.

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Guo, X., Liu, B., Liu, H. et al. Research advances in identification procedures of endocrine disrupting chemicals. Environ Sci Pollut Res 30, 83113–83137 (2023). https://doi.org/10.1007/s11356-023-27755-y

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