Implications of endocrine-disrupting chemicals on polycystic ovarian syndrome: A comprehensive review

Jala, Aishwarya; Varghese, Bincy; Kaur, Gurparmeet; Rajendiran, Karthikraj; Dutta, Ratul; Adela, Ramu; Borkar, Roshan M.

doi:10.1007/s11356-022-21612-0

Implications of endocrine-disrupting chemicals on polycystic ovarian syndrome: A comprehensive review

Review Article
Published: 01 July 2022

Volume 29, pages 58484–58513, (2022)
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Environmental Science and Pollution Research Aims and scope Submit manuscript

Aishwarya Jala¹^na1,
Bincy Varghese²^na1,
Gurparmeet Kaur²,
Karthikraj Rajendiran³,
Ratul Dutta⁴,
Ramu Adela² &
…
Roshan M. Borkar ORCID: orcid.org/0000-0003-1963-7688¹

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Abstract

Polycystic ovarian syndrome (PCOS) is a complex multifactorial disorder of unknown pathogenesis in which genetic and environmental factors contribute synergistically to its phenotypic expressions. Endocrine-disrupting chemicals (EDCs), a group of widespread pollutants freely available in the environment and consumer products, can interfere with normal endocrine signals. Extensive evidence has shown that EDCs, environmental contributors to PCOS, can frequently induce ovarian and metabolic abnormalities at low doses. The current research on environmental EDCs suggests that there may be link between EDC exposure and PCOS, which calls for more human bio-monitoring of EDCs using highly sophisticated analytical techniques for the identification and quantification and to discover the underlying pathophysiology of the disease. This review briefly elaborated on the general etiology of PCOS and listed various epidemiological and experimental data from human and animal studies correlating EDCs and PCOS. This review also provides insights into various analytical tools and sample preparation techniques for biomonitoring studies for PCOS risk assessment. Furthermore, we highlight the role of metabolomics in disease-specific biomarker discovery and its use in clinical practice. It also suggests the way forward to integrate biomonitoring studies and metabolomics to underpin the role of EDCs in PCOS pathophysiology.

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Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs)

Article 01 December 2015

Associated Effects of Endocrine Disrupting Chemicals (EDCs) on Neuroendocrine Axes and Neurotransmitter Profile in Polycystic Ovarian Syndrome Condition

Article 30 November 2021

Demystifying Bisphenol A-Induced Alterations in Hypothalamic-Pituitary-Ovarian Functions Leading to Polycystic Ovarian Syndrome

Article 08 December 2021

Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

PCOS:: Polycystic ovarian syndrome
EDCs:: Endocrine-disrupting chemicals
PCOM:: Polycystic ovarian morphology
NIH:: National Institute of Health
PCBs:: Polychlorinated biphenyls
PFAS:: Per- and poly-fluoroalkyl substances
LC–MS/MS:: Liquid chromatography tandem mass spectrometry
GC-MS:: Gas chromatography mass spectrometry
GC:: Gas chromatography
LLE:: Liquid-liquid extraction
SPE:: Solid-phase extraction
TST:: Total and free testosterone
DHEA:: Dehydroepiandrosterone
DHEAS:: Dehydroepiandrosterone sulfate
A4:: Androstenedione
17-OHP:: 17-Hydroxy progesterone
LH:: Luteinizing hormone
SHBG:: Sex hormone binding globulin
FSH:: Follicular-stimulating hormone
IGF-1:: Insulin growth factor-1
AMH:: Anti-Mullerian hormone
GnRH:: Gonadotropin-releasing hormone
DHT:: Dihydrotestosterone
AGEs:: Advanced glycation end products
RAGE:: Receptor for advance glycation end products
HAD:: Hospital Anxiety and Depression
HPTE:: 2,2-Bis(p-hydroxyphenyl)-1,1, 1-trichloroethane
MEP:: Mono-ethyl phthalate
MnBP:: Mono-n-butyl phthalate
MiBP:: Mono-iso-butyl phthalate
MBzP:: Monobenzyl phthalate
MPP:: Mono-n-pentyl phthalate
MEHP:: Mono-(2-ethylhexyl) phthalate
MECPP:: Mono(2-ethyl-5- carboxypentyl) phthalate
MOP:: Mono-octyl phthalate
MiNP:: Mono-iso-nonyl phthalate
MCiOP:: Mono-carboxyiso- nonyl phthalate
MiDP:: Mono-iso-decyl phthalate
MXC:: Methoxychlor
LPME:: Liquid-phase microextraction
DLLME:: Dispersive liquid–liquid microextraction
SLMME:: Solid-phase supported liquid membrane microextraction
HF-LPME:: Hollow-fiber LPME
VALLME:: Vortex-assisted liquid–liquid microextraction
SDME:: Single-drop microextraction
USAEME:: Ultrasound-assisted emulsification microextraction
AALLME:: Air-assisted liquid–liquid microextraction
ILs:: Ionic liquids
DEHP:: Di(2-ethylhexyl)phthalate
MEHP:: Mono(2-ethylhexyl)phthalate (MEHP)
MEPS:: Microextraction by packed sorbents
MIPs:: Molecular imprinted polymers
HPLC:: High-performance liquid chromatography
CE:: Capillary electrophoresis
PDA:: Photodiode array detection
ECD:: Electrochemical detection
FLD:: Fluorescence detection
MS:: Mass detection
EI:: Electron ionization
ESI:: Electrospray ionization
IS:: Internal standard
MRM:: Multiple reaction monitoring
Q-TOF:: Quadrupole time-of-flight
FAI:: Free androgen index
PCBs:: Polychlorinated biphenyls
PFCs:: Perfluorinated compounds
BPA:: Bisphenol A
mBzP:: Mono-benzyl phthalate
mBP:: Mono-butyl phthalate
ELISA:: Enzyme-linked immunosorbent assays
StAR:: Steroidogenic acute regulatory protein
9-HODE:: 9-Hydroxyoctadecadienoic acid
13-HODE:: 13-Hydroxyoctadecadienoic acid
LPCs:: Lysophosphatidylcholines

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Acknowledgements

We acknowledge the support from Dr. U.S.N. Murty, Director, National Institute of Pharmaceutical Education and Research, Guwahati, India.

Funding

The authors received funding from Institutional Core Grant, NIPER-Guwahati, Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Govt. of India.

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Aishwarya Jala and Bincy Varghese contributed equally to this work.

Authors and Affiliations

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, 781101, India
Aishwarya Jala & Roshan M. Borkar
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, 781101, India
Bincy Varghese, Gurparmeet Kaur & Ramu Adela
Wadsworth Center, New York State Department of Health, Albany, NY, 12201-0509, USA
Karthikraj Rajendiran
Down Town Hospital, Guwahati, Assam, 781106, India
Ratul Dutta

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Aishwarya Jala
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Ratul Dutta
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Ramu Adela
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AJ and BV: conceptualization, visualization, resources, writing original draft preparation; GK: resources, writing original draft preparation; RD, RA, and KR: visualization, writing-reviewing, and editing; RMB and RA: conceptualization, writing—reviewing, and editing, supervision.

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Jala, A., Varghese, B., Kaur, G. et al. Implications of endocrine-disrupting chemicals on polycystic ovarian syndrome: A comprehensive review. Environ Sci Pollut Res 29, 58484–58513 (2022). https://doi.org/10.1007/s11356-022-21612-0

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