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Bisphenol A exposure and abnormal glucose tolerance during pregnancy: systematic review and meta-analysis

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Abstract

In the present work, a systematic review and meta-analysis were performed to examine the probable relation between maternal exposure to bisphenol A (BPA), as estrogen-disrupting compounds, and gestational diabetes mellitus (GDM), and impaired glucose tolerance (IGT). We comprehensively searched three electronic databases to retrieve published studies on maternal exposure to BPA and GDM/IGT, through February 2021. Cochran’s Q test and I2 statistics were employed for testing heterogeneity across studies. DerSimonian and Liard random-effects model was used to determine the pooled estimates. Otherwise, the fixed-effects model with inverse-variance weights was applied. Sensitivity analysis was performed to determine the robustness of the results by excluding each study from the pooled estimate. The potential publication bias was examined using Begg’s and Egger’s tests. The pooled odds ratio did not show BPA exposure to be a significant risk factor for GDM (OR = 0.90, 95% CI = 0.62–1.33, I2: 50.7%). Also, no significant association was observed between BPA exposure and risk of IGT (OR = 0.93, 95% CI = 0.40–2.18, I2: 11.5%). Based on the findings of this study, no association was found between exposure to BPA during pregnancy and the risk of GDM/IGT. Albeit no heterogeneity was found between studies.

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Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Acknowledgements

Consejo Nacional de Ciencia y Tecnología (CONACYT) is thankfully acknowledged for partially supporting this work under Sistema Nacional de Investigadores (SNI) program awarded to Hafiz M.N. Iqbal (CVU: 735340).

Funding

This work was supported by the Isfahan University of Medical Sciences of Iran.

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Authors and Affiliations

  1. Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

    Ensiyeh Taheri & Ali Fatehizadeh

  2. Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

    Ensiyeh Taheri, Nasim Rafiei & Ali Fatehizadeh

  3. Department of Biostatistics & Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

    Roya Riahi & Sayed Mohsen Hosseini

  4. Student Research Committee, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

    Roya Riahi & Nasim Rafiei

  5. Tecnologico de Monterrey, School of Engineering and Sciences, 64849, Monterrey, Mexico

    Hafiz M.N. Iqbal

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  1. Ensiyeh Taheri
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  2. Roya Riahi
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  3. Nasim Rafiei
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  4. Ali Fatehizadeh
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  5. Hafiz M.N. Iqbal
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  6. Sayed Mohsen Hosseini
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Contributions

Ensiyeh Taheri contributed to most of the systemic review and manuscript draft preparation. Roya Riahi contributed to inclusion and exclusion criteria, quality assessment, data management, and statistical analysis. Nasim Rafiei contributed to the literature search and quality assessment. Ali Fatehizadeh contributed to inclusion and exclusion criteria and manuscript writing. Seyed-Mohsen Hosseini and Hafiz M.N. Iqbal reviewed and edited the final manuscript and communicated the submission. All authors read and approved the final manuscript.

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Correspondence to Hafiz M.N. Iqbal or Sayed Mohsen Hosseini.

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Taheri, E., Riahi, R., Rafiei, N. et al. Bisphenol A exposure and abnormal glucose tolerance during pregnancy: systematic review and meta-analysis. Environ Sci Pollut Res 28, 62105–62115 (2021). https://doi.org/10.1007/s11356-021-16691-4

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