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The protective role of lycopene against toxic effects induced by the herbicide Harness® and its active ingredient acetochlor on the African catfish Clarias gariepinus (Burchell, 1822)

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Abstract

The effects of Harness® toxicity on fish health are little known. So, current work aimed to study the impact of sub-lethal doses of Harness® (an acetochlor-based herbicide) on the African catfish, Clarias gariepinus, and also investigated the potential role of lycopene (LYCO) administration in alleviating Harness® negative effects. Fish were divided into five groups in triplicates as follows: group 1 (control) received no treatment, group 2 was exposed to 10 μm Harness®/L, group 3 was orally administered 10 mg LYCO/kg body weight and exposed to 10 μm Harness®/L, group 4 was exposed to 100 μm Harness®/L, and group 5 was orally administered 10 mg LYCO/kg body weight and exposed to 100 μm Harness®/L for 2 weeks. Some hemato-biochemical parameters, genotoxicity, and histopathological changes were assessed at the end of this period. Sub-lethal doses of Harness® altered the shape of erythrocytes in contrast to the control sample. Also, hematological parameters of exposed fish exhibited a significant (P < 0.05) reduction in the values of red blood cell count (RBCs), hemoglobin (Hb), hematocrit (HCT), and platelets (PL), as well as an insignificant (P > 0.05) drop in mean corpuscular volume (MCV). Harness® was also found to cause genotoxicity as well as histopathological alterations. LYCO administration decreased hemato-biochemical changes and returned them to near-normal levels. The findings showed that LYCO administration (10 mg LYCO/kg body weight) decreased Harness® toxicity in C. gariepinus and alleviated its destructive effects.

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Authors and Affiliations

  1. Zoology Department, Faculty of Sciences, Assiut University, Assiut, 71516, Egypt

    Alaa El-Din H. Sayed

  2. Department of Zoology, Faculty of Science, Al-Azhar University (Assiut Branch), Assiut, 71524, Egypt

    Mohamed Hamed

  3. Department of Zoology, Faculty of Science, Sohag University, Sohag, 8562, Egypt

    Hamdy A.M. Soliman

  4. Hydrobiology Department, National Research Centre, Dokki, Giza, 12622, Egypt

    Mohammad M. N. Authman

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  1. Alaa El-Din H. Sayed
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  2. Mohamed Hamed
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  3. Hamdy A.M. Soliman
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  4. Mohammad M. N. Authman
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Contributions

Experimental design: AHS, MH, and HAMS. Experiment and analysis: AHS, MH, and HAMS. Data interpretation: AHS, MH, HAMS, and MMNA. Writing and revision: AHS, MH, HAMS, and MMNA. All authors read and approved the final manuscript.

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Correspondence to Alaa El-Din H. Sayed.

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Ethics approval

Experimental setup, guidelines, and fish handling were approved by the Research and Ethical Committee of the Faculty of Science, Assiut University, Assiut, Egypt.

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The authors declare no competing interests.

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Sayed, A.ED.H., Hamed, M., Soliman, H.A. et al. The protective role of lycopene against toxic effects induced by the herbicide Harness® and its active ingredient acetochlor on the African catfish Clarias gariepinus (Burchell, 1822). Environ Sci Pollut Res 29, 14561–14574 (2022). https://doi.org/10.1007/s11356-021-16518-2

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