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Evaluation of ameliorative effect of two selected plant drugs on experimentally induced arsenic toxicity in sheep

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Abstract

Chronic arsenic poisoning is one of the serious health hazards in West Bengal, India, and Bangladesh. It occurs due to contaminated subsoil water. The aim of this study is conducted to find out the ameliorative effect of turmeric and P. foetida powder on experimentally induced arsenic toxicity in sheep. Twelve sheep were divided into four groups; groups I, II and III were orally administered with sodium arsenite at 6.6 mg/kg body weight for 133 days; groups I and II animals were treated by turmeric and P. foetida powders respectively at 500 mg/kg dose for the last 49 days; the fourth group was control. Arsenic content was estimated in faeces, urine and wool in every 15 days. Biochemical, haematological, antioxidant parameters and DNA fragmentation were also assessed. Turmeric and P. foetida powder treatment significantly (P < 0.05) increased arsenic elimination through faeces, urine and wool. Haemoglobin content and TEC were decreased in groups I, II and III; however, these were improved significantly (P < 0.05) by turmeric and P. foetida powder treatment. Increased activity of AST, ALT, blood urea nitrogen and plasma creatinine were significantly (P < 0.05) decreased in groups I and II. The reduced SOD and catalase activity were significantly (P < 0.05) restored at the end of the experiment in turmeric and P. foetida-treated groups. The test drugs are found significantly effective not only to eliminate arsenic from the body but also give protection from possible damage caused by arsenic exposure in sheep.

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Funding

This study received financial assistance from the Department of Pharmacology & Toxicology, West Bengal University of Animal & Fishery Sciences, Kolkata, West Bengal. This experiment was also supported by World Bank funded project of ‘National Agriculture Innovative Project’ entitled ‘Arsenic in food chain and its cause effect and mitigation’ sponsored by Indian Council for Agricultural Research, New Delhi, India.

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Authors and Affiliations

  1. North 24 Paraganas Krishi Vigyan Kendra, Ashokenagar, 743223, West Bengal, India

    Chinmoy Maji

  2. Department of Avian Sciences, Faculty of Veterinary & Fishery Sciences, Mohanpur, Nadia, 741252, West Bengal, India

    Suman Biswas

  3. J. B. Roy State Ayurvedic Medical College and Hospital, West Bengal University of Health Sciences, 170-172, Raja Dinendra Street, Kolkata, West Bengal, 700004, India

    Prasanta Kumar Sarkar

  4. Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata, India

    Pabitra Hriday Patra & Tapan Kumar Mandal

  5. Division of Veterinary Medicine, Indian Veterinary Research Institute-Eastern Regional Campus, Kolkata, India

    Samiran Bandyopadhyay

  6. Department of Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata, India

    Samar Sarkar

  7. Institute of Post Graduate Ayurvedic Education and Research, West Bengal University of Health Sciences, Kolkata, West Bengal, 700009, India

    Abichal Chattopadhyay

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  1. Chinmoy Maji
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Correspondence to Prasanta Kumar Sarkar.

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Maji, C., Biswas, S., Sarkar, P.K. et al. Evaluation of ameliorative effect of two selected plant drugs on experimentally induced arsenic toxicity in sheep. Environ Sci Pollut Res 27, 36744–36753 (2020). https://doi.org/10.1007/s11356-020-09569-4

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  • DOI: https://doi.org/10.1007/s11356-020-09569-4

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