Abstract
Agricultural activities in the Caribbean, especially banana cropping, are known for their significant use of pesticides. In particular is chlordecone, which was used between 1972 and 1993 against the banana root borer, Cosmopolites sordidus (Germar, 1824). In this context, “Kannari study: Health, Nutrition and Exposition to Chlordecone in French West Indies” was put in place in 2013–2014 to supplement knowledge about the exposure of the population to chlordecone and other organochlorine pollutants. The data collected comprised a dietary intake description, data from biological samples (blood sample), socioeconomic and demographic information, and data from complementary specific items relative to life habits. A total of 742 subjects (292 in Guadeloupe and 450 in Martinique) were included in the impregnation component of the Kannari study. In this study, chlordecone and organochlorine compounds were detected in almost all participants. This result suggests that exposure to chlordecone is widespread, but also to other organochlorine pesticides. Chlordecone impregnation of the majority of the population appears to have decreased between 2003 and 2013, but various subgroups of the population remain highly exposed. The levels of impregnation are determined by dietary exposure and environmental contamination. However, total consumption of fresh fish (all species combined), especially from informal channels, is the main source of exposure to chlordecone. The serum PCB concentrations measured in the French Caribbean Islands of Guadeloupe and Martinique are lower than those observed in metropolitan France in 2007 (French Nutrition and Health Survey (ENNS)). In contrast, the French West Indies population seems more exposed to lindane than the French mainland population, and this exposure also seems more recent.
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References
Afssa (2007) Actualisation de l'exposition alimentaire au chlordécone de la population antillaise. Agence française de sécurité sanitaire des aliments, Maisons-Alfort, p 51
Cannon SB, Veazey JM Jr, Jackson RS, Burse VW, Hayes C, Straub WE, Landrigan PJ, Liddle JA (1978) Epidemic kepone poisoning in chemical workers. Am J Epidemiol 107(6):529–537
Cohn WJ, Boylan JJ, Blanke RV, Fariss MW, Howell JR, Guzelian PS (1978) Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial. N Engl J Med 298(5):243–248
Deloumeaux J, Bhakkan B, Eyraud R, Braud F, Manip M'Ebobisse N, Blanchet P, Brureau L (2017) Prostate cancer clinical presentation, incidence, mortality and survival in Guadeloupe over the period 2008-2013 from a population-based cancer registry. Cancer Causes Control 28(11):1265–1273
Dromard CR, Bodiguel X, Lemoine S, Bouchon-Navaro Y, Reynal L, Thouard E, Bouchon C (2016) Assessment of the contamination of marine fauna by chlordecone in Guadeloupe and Martinique (Lesser Antilles). Environ Sci Pollut Res Int 23(1):73–80
Dubuisson C, Heraud F, Leblanc JC, Gallotti S, Flamand C, Blateau A, Quenel P, Volatier JL (2007) Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to Chlordecone. Regul Toxicol Pharmacol 49(1):5–16
Fournier A, Feidt C, Lastel ML, Archimede H, Thome JP, Mahieu M, Rychen G (2017) Toxicokinetics of chlordecone in goats: implications for risk management in French West Indies. Chemosphere 171:564–570
Frery, N., L. Guldner, A. Saoudi, R. Garnier, A. Zeghnoun, and M. L. Bidondo. 2013. Exposition de la population française aux substances chimiques de l'environnement. Tome 2. Polychlorobiphényles (PCB-NDL) et pesticides, edited by s. Institut de veille. Saint-Maurice, 178
Guldner L, Multigner L, Heraud F, Monfort C, Thome JP, Giusti A, Kadhel P, Cordier S (2010) Pesticide exposure of pregnant women in Guadeloupe: ability of a food frequency questionnaire to estimate blood concentration of chlordecone. Environ Res 110(2):146–151
Hamilton, L. C., 2012. Statistics with Stata: version 12. Cengage Learning
Hammond B, Katzenellenbogen BS, Krauthammer N, McConnell J (1979) Estrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors. Proc Natl Acad Sci U S A 76(12):6641–6645
Kadhel P, Monfort C, Costet N, Rouget F, Thome JP, Multigner L, Cordier S (2014) Chlordecone exposure, length of gestation, and risk of preterm birth. Am J Epidemiol 179(5):536–544
Little Roderick, J. A., and B. Rubin Donald. 2002. Statistical analysis with missing data. Wiley series in probability and statistics. Second edition. New York: Wiley Series in Probability and Statistics
Multigner, L., and P. Kadhel. 2008. Exposition à des polluants environnementaux chez la femme enceinte et son enfant en Guadeloupe. Niveaux de chlordécone dans le sang maternel et étude des déterminants de l’imprégnation. In Rapport complémentaire: INSERM U625 & Service Gynécologie-Obstétrique CHU Pointe à Pitre
Multigner L, Kadhel P, Pascal M, Huc-Terki F, Kercret H, Massart C, Janky E, Auger J, Jegou B (2008) Parallel assessment of male reproductive function in workers and wild rats exposed to pesticides in banana plantations in Guadeloupe. Environ Health 7:40
Multigner, L., J. R. Ndong, A. Giusti, M. Romana, H. acroix-Maillard, S. Cordier, B. Jegou, J. P. Thome, and P. Blanchet. 2010. Chlordecone exposure and risk of prostate cancer. J Clin Oncol 28 (21):3457–3462
Reuber MD (1979) The carcinogenicity kepone. J Environ Pathol Toxicol 2(3):671–686
Royston P, Altman DG, Sauerbrei W (2006) Dichotomizing continuous predictors in multiple regression: a bad idea. Stat Med 25(1):127–141
Royston, P., and I. R. White. 2011. Multiple Imputation by Chained Equations (MICE): Implementation in Stata. Journal of Statistical Software; Vol 1, Issue 4 (2011)
Taylor JR, Selhorst JB, Houff SA, Martinez AJ (1978) Chlordecone intoxication in man. I Clinical observations Neurology 28(7):626–630
Zanuttini C, Gally F, Scholl G, Thome JP, Eppe G, Das K (2019) High pollutant exposure level of the largest European community of bottlenose dolphins in the English Channel. Sci Rep 9(1):12521
Acknowledgments
The authors acknowledge all the participants of the Kannari study and the many stakeholders: the regional health agencies of Martinique and Guadeloupe, the hospital in Martinique (CHUM), the Pasteur Institute in Guadeloupe, the nurses and the medical biology analysis laboratories, the French National Institute for Statistical and Economic Studies, the regional health observatories (ORSag and OSM), Catherine Adam from the laboratory of Animal Ecology and Ecotoxicology, Center of Analytical Research and Technology (CART), for her invaluable assistance in carrying out micropollutant analyses, and the people of the regional delegation of Santé Publique France.
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Dereumeaux, C., Saoudi, A., Guldner, L. et al. Chlordecone and organochlorine compound levels in the French West Indies population in 2013–2014. Environ Sci Pollut Res 27, 41033–41045 (2020). https://doi.org/10.1007/s11356-019-07181-9
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DOI: https://doi.org/10.1007/s11356-019-07181-9