Skip to main content

Advertisement

Log in

Metals and metalloids in traditional medicines (Ayurvedic medicines, nutraceuticals and traditional Chinese medicines)

  • Review Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

Traditional medicine (TM) including Ayurvedic medicines, traditional Chinese medicines and nutraceuticals are popular across the globe as dietary supplements and traditional and alternative medicines. Health risks from these remedies continue to present serious concerns, with occurrences of poisoning by metals and metalloids present at concentrations above acceptable regulatory standards. This review overviews the prevalence of TM use, cases of metal and metalloid poisoning following TM consumption, and forms of TM contamination and adulteration. The review summarises regulations by the World Health Organization (WHO) and other relevant bodies. Finally, the review recommends how to protect consumers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Abba D, Inabo HL, Yakubu SE, Olonitola OS (2009) Contamination of herbal medicinal products marketed in Kaduna metropolis with selected pathogenic bacteria. Afr J Tradit Complement Altern Med 6(1):70–77

    Google Scholar 

  • Abou-Arab K, Kawther MS, Tantawy EL, Badeaa RI, Khariya N (1999) Quantity estimation of some contaminants in commonly used medicinal plants in the Egyptian market. Food Chem 67:357–363

    Article  CAS  Google Scholar 

  • Agbabiaka TB, Pittler MH, Wider B, Ernst E (2009) Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 32(8):637–647

    Article  Google Scholar 

  • Al Faraj S (2005) Antagonism of the anticoagulant effect of warfarin caused by the use of Commiphora molmol as a herbal medication: a case report. Ann Trop Med Parasitol 99(2):219–220

    Article  Google Scholar 

  • Almela C, Algora S, Benito V, Clemente MJ, Devesa V, Suner MA, Montoro R (2002) Heavy metal, total arsenic, and inorganic arsenic contents of algae food products. J Agric Food Chem 50(4):918–923

    Article  CAS  Google Scholar 

  • Alsanad SM, Williamson EM, Howard RL (2014) Cancer patients at risk of herb/food supplement–drug interactions: a systematic review. Phytother Res 28(12):1749–1755

    Article  Google Scholar 

  • Amster E, Tiwary A, Schenker MB (2007) Case report: potential arsenic toxicosis secondary to herbal kelp supplement. Environ Health Perspect 115(4):606–608

    Article  CAS  Google Scholar 

  • Araujo J, Beelen A, Lewis L, Robinson G, DeLaurier C, Carbajal M, Kales S (2004) Lead poisoning associated with Ayurvedic medications-five states, 2000–2003. Morb Mortal Wkly Rep 53(26):582–584

    Google Scholar 

  • Aslam M, Davis S, Healy M (1979) Heavy metals in some Asian medicines and cosmetics. Public Health 93(5):274–284

    Article  CAS  Google Scholar 

  • ASTDR (2012) Toxicological profile for cadmium. Available at http://www.atsdr.cdc.gov/toxprofiles/tp5. Accessed 2Apr18.

  • Au A, Ko R, Boo F, Hsu R, Perez G, Yang Z (2000) Screening methods for drugs and heavy metals in Chinese patent medicines. Bull Environ Contam Toxicol 65(1):112–119

    Article  CAS  Google Scholar 

  • Auyeung TW, Chang KK, To CH, Mak A, Szeto ML (2002) Three patients with lead poisoning following use of a Chinese herbal pill. Hong Kong medical journal= Xianggang yi xue za zhi 8(1):60–62

    CAS  Google Scholar 

  • Aziz N, Gilani A, Rindh M (2002) Kushta(s): unique herbo-mineral preparations used in South Asian traditional medicine. Med Hypotheses 59(4):468–472

    Article  CAS  Google Scholar 

  • Bagchi D (2006) Nutraceuticals and functional foods regulations in the United States and around the world. Toxicology 221(1):1–3

    Article  CAS  Google Scholar 

  • Bajaj S, Vohora SB (2000) Anti-cataleptic, anti-anxiety and anti-depressant activity of gold preparations used in Indian system of medicine. Indian J Pharm 32(6):339–346

    CAS  Google Scholar 

  • Barton AL, McLean B (2013) An unusual case of peripheral neuropathy possibly due to arsenic toxicity secondary to excessive intake of dietary supplements. Ann Clin Biochem 50(5):496–500

    Article  Google Scholar 

  • Bateman J, Chapman RD, Simpson D (1998) Possible toxicity of herbal remedies. Scott Med J 43(1):7–15

    Article  CAS  Google Scholar 

  • Bayly G, Braithwaite R, Sheehan T, Dyer N, Grimley C, Ferner R (1995) Lead poisoning from Asian traditional remedies in the West Midlands-report of a series of five cases. Hum Exp Toxicol 14(1):24–28

    Article  CAS  Google Scholar 

  • Beijnen JH, Schellens JH (2004) Drug interactions in oncology. The Lancet Oncology 5(8):489–496

    Article  CAS  Google Scholar 

  • Bensoussan A, Myers SP (1996) Towards a safer choice: the practice of traditional Chinese medicine in Australia. Faculty of Health, University of Western Sydney Macarthur, Campbelltown, NSW

    Google Scholar 

  • Bhattacharya P, Frisbie S, Smith E, Naidu R, Jacks G, Sarkar B (2002) Arsenic in the environment: a global perspective. Handbook of heavy metals in the environment. Marcell Dekker Inc., New York, pp 147–215

    Google Scholar 

  • Biswas JK, Rai M, Mondal M, Ingle AP (2018) The flop side of using heavy metal (loids) s in the traditional medicine: toxic insults and injury to human health. In Biomedical Applications of Metals Springer, Cham: 257–276

  • Bolan S, Kunhikrishnanc A, Seshadria B, Choppala G, Naidu R, Bolan NS, Ok YS, Zhang M, Li C-G, Li F, Noller B, Kirkham MB (2017) Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal (loid) s in complementary medicines. Environ Int 108:103–118

    Article  CAS  Google Scholar 

  • Bolan S, Naidu R, Kunhikrishnan A, Seshadri B, Ok YS, Palanisami T, Clark I (2016) Speciation and bioavailability of lead in complementary medicines. Sci Total Environ 539:304–312

    Article  CAS  Google Scholar 

  • Brower V (1998) Nutraceuticals: poised for a healthy slice of the healthcare market? Nat Biotechnol 16:728–731

    Article  CAS  Google Scholar 

  • Cassileth BR, Lucarelli CD (2003) Herb-drug interactions in oncology. Peoples Medical Publishing House Limited-United States of America, Shelton, 480 pp

    Google Scholar 

  • Chan K (2003) Some aspects of toxic contaminants in herbal medicines. Chemosphere 52(9):1361–1371

    Article  CAS  Google Scholar 

  • Chan TY, Critchley JA (1996) Usage and adverse effects of Chinese herbal medicines. Hum Exp Toxicol 15(1):5–12

    Article  CAS  Google Scholar 

  • Chan H, Yeh YY, Billmeier GJ, Evans WE, Chan H (1977) Lead poisoning from ingestion of Chinese herbal medicine. Clin Toxicol 10(3):273–281

    Article  CAS  Google Scholar 

  • Chopra A, Doiphode V (2002) Ayurvedic medicine. Core concept, therapeutic principles and current relevance. Med Clin N Am 86:75–89

    Article  Google Scholar 

  • Coon JT, Pittler M, Ernst E (2003) Herb-drug interactions: a survey of leading pharmaceutical/herbal companies. Arch Intern Med 163(11):1371

    Article  Google Scholar 

  • Cooper EL (2005) CAM, eCAM, bioprospecting: the 21st-century pyramid. Evid Based Complement Alternat Med 2(2):125–128

    Article  Google Scholar 

  • Cooper K, Noller B, Connell D, Yu J, Sadler R, Olszowy H, Golding G, Tinggi U, Moore MR, Myers S (2007) Public health risks from heavy metals and metalloids present in traditional Chinese medicines. J Toxic Environ Health A 70:1694–1699

    Article  CAS  Google Scholar 

  • Coppens P, da Silva MF, Pettman S (2006) European regulations on nutraceuticals, dietary supplements and functional foods: a framework based on safety. Toxicology 221:9–74

    Article  CAS  Google Scholar 

  • Dargan PI, Gawarammana IB, Archer JR, House IM, Shaw D, Wood D (2008) Heavy metal poisoning from Ayurvedic traditional medicines: an emerging problem? Int J Environ Health 2(3–4):463–474

    Article  CAS  Google Scholar 

  • De Smet PAGM (2004) Health risks of herbal remedies: an update. Clin Pharmacol Ther 76(1):1–17

    Article  Google Scholar 

  • DeFelice SL (1992) Nutraceuticals: opportunities in an emerging market. Scrip Magazine, 9. Available at www.fimdefelice.org/p2463.html. Accessed 11 February 2019

  • Destro MWB, Speranzini MB, Cavalheiro Filho C, Destro T, Destro C (2005) Bilateral haematoma after rhytidoplasty and blepharoplasty following chronic use of Ginkgo biloba. Br J Plast Surg 58(1):100–101

    Article  CAS  Google Scholar 

  • Devla MN, Acharya SR, Acharya NS, Kumar V (2011) Dietary supplements: a legal status in India and in foreign countries. Int J Pharm Pharm Sci 3(3):7–12

    Google Scholar 

  • Dolan G, Jones AP, Blumsohn A, Reilly JT, Brown MJ (1991) Lead poisoning due to Asian ethnic treatment for impotence. J R Soc Med 84(10):630–631

    CAS  Google Scholar 

  • DSHEA (Dietary Supplement Health and Education Act). 1994. Public Law No. 103–417, 108 Stat. 4325, 21 U.S.C

  • Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC (1998) Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national survey. J Am Med Assoc 280(18):1569–1575

    Article  CAS  Google Scholar 

  • El Sheikha AF (2017) Medicinal plants: ethno-uses to biotechnology era. In: Malik S (ed) Biotechnology and production of anti-cancer compounds. Springer, Cham

    Google Scholar 

  • Ernst E (2002) Heavy metals in traditional Indian remedies. Eur J Clin Pharmacol 57(12):891–896

    Article  CAS  Google Scholar 

  • Ernst E, Coon JT (2001) Heavy metals in traditional Chinese medicines: a systematic review. Clin Pharmacol Ther 70(6):497–504

    Article  CAS  Google Scholar 

  • Espinoza EO, Mann MJ, Bleasdell B (1995) Arsenic and mercury in traditional Chinese herbal balls. N Engl J Med 333(12):803–804

    Article  CAS  Google Scholar 

  • FAO/WHO (2010) Expert Committee on Food Additives. Summary report of the seventy-second meeting of JECFA, 16th–26th February 2010. JECFA/72/SC, 8–10

  • Fewtrell L, Kaufmann R, Prüss-Üstün A (2003) Lead: assessing the environmental burden of disease at national and local levels. Geneva, World Health Organization. Environmental burden of disease series, no.2, 73 pp.

  • Food Safety and Standards Authority of India (FSSAI) (2016) Food safety and standards (health supplements, nutraceuticals, food for special dietary use, food for special medical purpose, functional food and novel food) regulations, 2016

  • Gair R (2008) Heavy metal poisoning from Ayurvedic medicines. B C Med J 50(2):105

    Google Scholar 

  • Garrett GR (2010) Natural sources of metals to the environment. Hum Ecol Risk Assess: Int J 6(6):945–963

    Article  Google Scholar 

  • Genuis SJ, Schwalfenberg G, Siy AKJ, Rodushkin I (2012) Toxic element contamination of natural health products and pharmaceutical preparations. PLoS One 7(11):e49676

    Article  CAS  Google Scholar 

  • Gershwin ME, Borchers AT, Keen CL, Hendler S, Hagie F, Greenwood MRC (2010) Public safety and dietary supplementation. Ann N Y Acad Sci 1190(1):104–117

    Article  Google Scholar 

  • Ghodke Y, Joshi K, Patwardhan B (2011) Traditional medicine to modern pharmacogenomics: Ayurveda Prakriti type and CYP2C19 gene polymorphism associated with the metabolic variability. Evid Based Complement Alternat Med: eCAM 2011:249528

    Article  Google Scholar 

  • Giacomino A, Abollino O, Malandrino M, Karthik M, Murugesan V (2011) Determination and assessment of the contents of essential and potentially toxic elements in Ayurvedic medicine formulations by inductively coupled plasma-optical emission spectrometry. Microchem J 99(1):2–6

    Article  CAS  Google Scholar 

  • Gogtay NJ, Bhatt HA, Dalvi SS, Kshirsagar NA (2002) The use and safety of non-allopathic Indian medicines. Drug Saf 25(14):1005–1019

    Article  CAS  Google Scholar 

  • Graham RE, Ahn AC, Davis RB, O'Connor BB, Eisenberg DM, Phillips RS (2005) Use of complementary and alternative medical therapies among racial and ethnic minority adults: results from the 2002 National Health Interview Survey. J Natl Med Assoc 97(4):535–645

    Google Scholar 

  • Grimstein M, Huang SM (2018) A regulatory science viewpoint on botanical-drug interactions. J Food Drug Anal 26(2):12–25

    Article  CAS  Google Scholar 

  • Gunturu KS, Nagarajan P, McPhedran P, Goodman TR, Hodsdon ME, Strout MP (2011) Ayurvedic herbal medicine and lead poisoning. J Haematol Oncol 4(1):51–57

    Article  Google Scholar 

  • Gupta N, Goswami B, Singh N, Koner BC, Garg R (2011) Lead poisoning associated with Ayurvedic drug presenting as intestinal obstruction: a case report. Clin Chim Acta 412(1–2):213–214

    Article  CAS  Google Scholar 

  • Hathcock JN (1997) Vitamins and minerals: efficacy and safety. Am J Clin Nutr 66(2):427–437

    Article  CAS  Google Scholar 

  • Health Canada (2016) About natural health product regulations in Canada - Health Canada. Available at http://www.hc-sc.gc.ca/dhp-mps/prodnatur/about-apropos/index-eng.php. Accessed 2 May 2018

  • Heck AM, Dewitt BA, Lukes AL (2000) Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 57(13):1221–1227

    Article  CAS  Google Scholar 

  • Hochholzer K, Li W, Gunja N (2014) A heavy burden: remaining vigilant with herbal remedies. Aust Fam Physician 43(8):545–546

    Google Scholar 

  • Hu XY, Lorenc A, Kemper K, Liu JP, Adams J, Robinson N (2015) Defining integrative medicine in narrative and systematic reviews: a suggested checklist for reporting. Eur J Integrative Med 7(1):76–84

    Article  Google Scholar 

  • Huang RJ, Zhuang ZX, Tai Y, Huang RF, Wang XR, Lee FS (2006) Direct analysis of mercury in traditional Chinese medicines using thermolysis coupled with on-line atomic absorption spectrometry. Talanta 68(3):728–734

    Article  CAS  Google Scholar 

  • International Agency for Research on Cancer (1990) Chromium. IARC Monogr Eval Carcinog Risks Hum 49:49–256

    Google Scholar 

  • International Agency for Research on Cancer (1993) Cadmium and certain cadmium compounds. In: IARC monographs on the evaluation of the carcinogenic risk of chemicals to man. Beryllium, cadmium, mercury and exposures in the glass manufacturing industry IARC monographs, Vol. 58. Lyon, France: World Health Organization, pp. 148–161

  • International Agency for Research on Cancer (2006) Inorganic and organic lead compounds. IARC Monogr Eval Carcinog Risks Hum 87:1–471

    Google Scholar 

  • International Atomic Energy Agency (1986) Derived intervention levels for application in controlling radiation doses to the public in the event of a nuclear emergency: principles, procedures and data. Vienna; Safety Series No. 81, 122 pp.

  • International Programme on Chemical Safety (1995). Inorganic lead. Geneva, World Health Organization, International Programme on Chemical Safety (Environmental Health Criteria 165). Available at http://www.inchem.org/documents/ehc/ehc/ehc165.htm. Accessed 07Sep2017

  • International Programme on Chemical Safety (1999) Arsenic. Geneva, WHO (Poison Information Monograph No. G042)

  • Izzo AA (2005) Herb-drug interactions: an overview of the clinical evidence. Fundam Clin Pharmacol 19(1):1–16

    Article  CAS  Google Scholar 

  • Izzo AA, Ernst E (2001) Interactions between herbal medicines and prescribed drugs. Drugs 61(15):2163–2175

    Article  CAS  Google Scholar 

  • Javed F, Golagani A, Sharp H (2008) Potential effects of herbal medicines and nutritional supplements on coagulation in ENT practice. J Laryngol Otol 122(2):116–119

    Article  CAS  Google Scholar 

  • Jung MC (2008) Heavy metal concentrations in soils and factors affecting metal uptake by plants in the vicinity of a Korean Cu-W mine. Sensors 8(4):2413–2423

    Article  Google Scholar 

  • Jung M, Park M, Lee HC, Kang YH, Kang ES, Kim SK (2006) Antidiabetic agents from medicinal plants. Curr Med Chem 13(10):1203–1218

    Article  CAS  Google Scholar 

  • Kabata-Pendias A (2001) Trace elements in soils and plants. CRC Press Inc., Boca Raton

    Google Scholar 

  • Kales SN, Christophi CA, Saper RB (2007) Hematopoietic toxicity from lead-containing Ayurvedic medications. Med Sci Monit 13(7):CR295–CR298

    CAS  Google Scholar 

  • Keen R, Deacon A, Delves H, Moreton J, Frost P (1994) Indian herbal remedies for diabetes as a cause of lead poisoning. Postgrad Med J 70(820):113–114

    Article  CAS  Google Scholar 

  • Khan IA, Allgood J, Walker LA, Abourashed EA, Schlenk D, Benson WHO (2001) Determination of heavy metals and pesticides in ginseng products. J AOAC Int 84(3):936–939

    CAS  Google Scholar 

  • Koch I, Moriarty M, House K, Sui J, Cullen WR, Saper RB, Reimer KJ (2011) Bioaccessibility of lead and arsenic in traditional Indian medicines. Sci Total Environ 409(21):4545–4552

    Article  CAS  Google Scholar 

  • Koh HL, Woo SO (2000) Chinese proprietary medicine in Singapore. Drug Saf 23(5):351–362

    Article  CAS  Google Scholar 

  • Kudolo GB, Dorsey S, Blodgett J (2002) Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and type 2 diabetic subjects. Thromb Res 108(2):151–160

    Article  CAS  Google Scholar 

  • Kulhari A, Sheorayan A, Bajar S, Sarkar S, Chaudhury A, Kalia RK (2013) Investigation of heavy metals in frequently utilized medicinal plants collected from environmentally diverse locations of north western India. SpringerPlus 2(1):676

    Article  CAS  Google Scholar 

  • Kumar CS, Moorthi C, Prabhu PC, Jonson BB, Venkatnarayan R (2011) Standardization of anti-arthritic herbo-mineral preparation. Res J Pharm, Biol Chem Sci 2:679–684

    Google Scholar 

  • Kumar A, Nair A, Reddy A, Garg A (2006) Availability of essential elements in bhasmas: analysis of Ayurvedic metallic preparations by INAA. J Radioanal Nucl Chem 270(1):173–180

    Article  CAS  Google Scholar 

  • Lawson KA, Wright ME, Subar A, Mouw T, Hollenbeck A, Schatzkin A, Leitzmann MF (2007) Multivitamin use and risk of prostate cancer in the National Institutes of Health–AARP Diet and Health Study. J Natl Cancer Inst 99(10):754–764

    Article  CAS  Google Scholar 

  • Leite PM, Martins MAP, Castilho RO (2016) Review on mechanisms and interactions in concomitant use of herbs and warfarin therapy. Biomed Pharmacother 83:14–21

    Article  Google Scholar 

  • Li AM, Chan MH, Leung T, Cheung RC, Lam CW, Fok T (2000) Mercury intoxication presenting with tics. Arch Dis Child 83(2):174–175

    Article  CAS  Google Scholar 

  • Lightfoote J, Blair HJ, Cohen JR (1977) Lead intoxication in an adult caused by Chinese herbal medication. J Am Med Assoc 238(14):1539–1539

    Article  CAS  Google Scholar 

  • Liu RH (2003) Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 78(3):517S–520S

    Article  CAS  Google Scholar 

  • Mandal BK, Suzuki KT (2002) Arsenic round the world: a review. Talanta 58(1):201–235

    Article  CAS  Google Scholar 

  • Markowitz SB, Nunez CM, Klitzman S, Munshi AA, Kim WS, Eisinger J, Landrigan PJ (1994) Lead poisoning due to hai ge fen: the porphyrin content of individual erythrocytes. J Am Med Assoc 271(12):932–934

    Article  CAS  Google Scholar 

  • Martena MJ, Van Der Wielen JC, Rietjens IM, Klerx WN, De Groot HN, Konings EJ (2010) Monitoring of mercury, arsenic, and lead in traditional Asian herbal preparations on the Dutch market and estimation of associated risks. Food Addit Contam 27(2):190–205

    Article  CAS  Google Scholar 

  • Martínez-Domínguez G, Plaza-Bolaños P, Romero-González R, Garrido-Frenich A (2014) Analytical approaches for the determination of pesticide residues in nutraceutical products and related matrices by chromatographic techniques coupled to mass spectrometry. Talanta 118:277–291

    Article  CAS  Google Scholar 

  • McLaughlin MJ, Parker DR, Clarke JM (1999) Metals and micronutrients–food safety issues. Field Crop Res 60(1–2):143–163

    Article  Google Scholar 

  • Melchart D, Wagner H, Hager S, Saller R, Ernst E (2001) Quality assurance and evaluation of Chinese medicinal drugs in a hospital of traditional Chinese medicine in Germany: a five-year report. Altern Ther Health Med 7:S24

    Google Scholar 

  • Meseguer E, Taboada R, Sánchez V, Mena MA, Campos V, García de Yébenes J (2002) Life-threatening parkinsonism induced by kava-kava. Mov Disord 17(1):195–196

    Article  Google Scholar 

  • Mikulski MA, Wichman MD, Simmons DL, Pham AN, Clottey V, Fuortes LJ (2017) Toxic metals in ayurvedic preparations from a public health lead poisoning cluster investigation. Int J Occup Environ Health 23(3):187–192

    Article  CAS  Google Scholar 

  • Miller WH, Schipper HM, Lee JS, Singer J, Waxman S (2002) Mechanisms of action of arsenic trioxide. Cancer Res 62(14):3893–3903

    CAS  Google Scholar 

  • Mitchell-Heggs C, Conway M, Cassar J (1990) Herbal medicine as a cause of combined lead and arsenic poisoning. Hum Exp Toxicol 9(3):195–196

    Article  CAS  Google Scholar 

  • Moreira DDL, Teixeira SS, Monteiro MHD, De-Oliveira ACA, Paumgartten FJ (2014) Traditional use and safety of herbal medicines. Rev Bras 24(2):248–257

    Google Scholar 

  • Mullins RJ, Heddle R (2002) Adverse reactions associated with echinacea: the Australian experience. Ann Allergy Asthma Immunol 88(1):42–51

    Article  Google Scholar 

  • Nahin RL, Barnes PM, Stussman BJ, Bloom B (2009) Costs of complementary and alternative medicine (CAM) and frequency of visits to CAM practitioners: the United States, 2007. Natl Health Stat Rep 18(18):1–14

    Google Scholar 

  • Nash KM, Shah ZA (2015) Current perspectives on the beneficial role of Ginkgo biloba in neurological and cerebrovascular disorders. Integrative Medicine Insights 10:1–9

    Article  Google Scholar 

  • Nouri J, Mahvi AH, Jahed GR, Babaei A (2008) A regional distribution pattern of groundwater heavy metals resulting from agricultural activities. Environ Geol 55:1337–1343

    Article  CAS  Google Scholar 

  • Okigbo RN, Mmeka EC (2006) An appraisal of phytomedicine in Africa. Curr Appl Sci Technol 6(2):83–94

    Google Scholar 

  • Page RL, Lawrence JD (1999) Potentiation of warfarin by dong quai. Pharmacother: J Hum Pharmacol Drug Ther 19(7):870–876

    Article  Google Scholar 

  • Palmer ME, Haller C, McKinney PE, Klein-Schwartz W, Tschirgi A, Smolinske SC, Nelson LS (2003) Adverse events associated with dietary supplements: an observational study. Lancet 361(9352):101–106

    Article  Google Scholar 

  • Pan SY, Litscher G, Gao SH, Zhou SF, Yu ZL, Chen HQ, Tang MK, Sun JN, Ko KM (2014) Historical perspective of traditional indigenous medical practices: the current renaissance and conservation of herbal resources. Evid Based Complement Alternat Med 2014:1–20

    Google Scholar 

  • Pharmacopoeia of China (2015) Pharmacopoeia of the People’s Republic of China, vol 1. Chemical Industry Press. 2015 ed., Beijing

    Google Scholar 

  • Pip E (1991) Cadmium, copper, and lead in soils and garden produce near a metal smelter at Flin Flon, Manitoba. Bull Environ Contam Toxicol 46(5):790–796

    Article  CAS  Google Scholar 

  • Rao MM, Kumar MA (2011) Detection of toxic heavy metals and pesticide residue in herbal plants which are commonly used in the herbal formulations. Environ Monit Assess 181(1–4):267–271

    Article  CAS  Google Scholar 

  • Reimer KJ, Koch I (2012) Metals and metalloids in complementary and alternative medicines. Maturitas 72(4):267–268

    Article  Google Scholar 

  • Robinson MM, Zhang X (2011) Traditional medicines: global situation, issues and challenges. The world medicines situation, 3rd edn. World Health Organisation, Geneva, pp 1–14

    Google Scholar 

  • Saito M (2007) Role of FOSHU (food for specified health uses) for a healthier life. Yakugaku zasshi: J Pharm Soc Jpn 127(3):407–416

    Article  CAS  Google Scholar 

  • Saper RB, Phillips RS, Sehgal A, Khouri N, Davis RB, Paquin J, Kales SN (2008) Lead, mercury, and arsenic in US-and Indian-manufactured Ayurvedic medicines sold via the Internet. J Am Med Assoc 300(8):915–923

    Article  CAS  Google Scholar 

  • Sarma H, Deka S, Deka H, Saikia RR (2011) Accumulation of heavy metals in selected medicinal plants. Rev Environ Contam Toxicol 214:63–86

    CAS  Google Scholar 

  • Saydah SH, Eberhardt MS (2006) Use of complementary and alternative medicine among adults with chronic diseases: the United States 2002. J Altern Complement Med 12(8):805–812

    Article  Google Scholar 

  • Shilo S, Hirsch HJ (1986) Iodine-induced hyperthyroidism in a patient with a normal thyroid gland. Postgrad Med J 62(729):661–662

    Article  CAS  Google Scholar 

  • Shimizu T (2003) Health claims and scientific substantiation of functional foods-Japanese system aiming the global standard. Curr Top Nutraceutical Res 1:213–224

    Google Scholar 

  • Sparreboom A, Cox MC, Acharya MR, Figg WD (2004) Herbal remedies in the United States: potential adverse interactions with anticancer agents. J Clin Oncol 22(12):2489–2503

    Article  CAS  Google Scholar 

  • Stefanovits-Bányai E, Szentmihályi K, Hegedűs A, Koczka N, Váli L, Taba G, Blázovics A (2006) Metal ion and antioxidant alterations in leaves between different sexes of Ginkgo biloba L. Life Sci 78(10):1049–1056

    Article  CAS  Google Scholar 

  • Straif K, Benbrahim-Tallaa L, Baan R, Grosse Y, Secretan B, El Ghissassi F, Cogliano V (2009) A review of human carcinogens-part C: metals, arsenic, dust, and fibres. The Lancet Oncology 10(5):453–454

    Article  Google Scholar 

  • Sultan S, Jahangir A, Gussak, IB, Kostis JB, JamilTajik A, Jahangir A (2018) Interactions between supplements and medications. Iatrogenicity: causes and consequences of iatrogenesis in cardiovascular medicine, 370–389

  • Taylor JR, Wilt VM (1999) Probable antagonism of warfarin by green tea. Ann Pharmacother 33(4):426–428

    Article  CAS  Google Scholar 

  • TGA. (2013) Listed complementary medicines | Therapeutic Goods Administration (TGA). Available at https://www.tga.gov.au/listed-complementary-medicines. Accessed 2 May 2018

  • TGA (2018) Australian regulatory guidelines for complementary medicines. Version, 7.2

  • Thatte UM, Rege NN, Phatak SD, Dahanukar SA (1993) The flip side of Ayurveda. J Postgrad Med 39(4):179–182

    CAS  Google Scholar 

  • Ting A, Chow Y, Tan W (2013) Microbial and heavy metal contamination in commonly consumed traditional Chinese herbal medicines. J Tradit Chin Med 33(1):119–124

    Article  Google Scholar 

  • Tripathi P, Dwivedi S, Mishra A, Kumar A, Dave R, Srivastava S, Tripathi RD (2012) Arsenic accumulation in native plants of West Bengal, India: prospects for phytoremediation but concerns with the use of medicinal plants. Environ Monit Assess 184(5):2617–2631

    Article  CAS  Google Scholar 

  • USEPA (1998) Support of summary information on the integrated risk information system (IRIS) Washington DC: toxicological review of hexavalent chromium (CAS no 18540-29-9)

  • Varghese T, Mishal P (2014) Scrutinising the term ‘nutraceutical’- a global regulatory perspective. Nutraceutical Business Review, 1–9. Available at https://www. nutraceuticalbusinessreview.com/news/article_page/Scrutinising_the_term_nutraceutical__a_global_regulatory_perspective/100047. Accessed: 3 May 2017

  • Vicentini A, Liberatore L, Mastrocola D (2016) Functional foods: trends and development of the global market. Ital J Food Sci 2:338–351

    Google Scholar 

  • Wadekar MP, Rode CV, Bendale YN, Patil KR, Prabhune AA (2005) Preparation and characterization of a copper-based Indian traditional drug: Tamra bhasma. J Pharm Biomed Anal 39(5):951–955

    Article  CAS  Google Scholar 

  • Walker AF, Marakis G, Morris AP, Robinson PA (2002) Promising hypotensive effect of hawthorn extract: a randomized double-blind pilot study of mild, essential hypertension. Phytother Res 16(1):48–54

    Article  Google Scholar 

  • Walkiw O, Douglas D (1975) Health food supplements prepared from a kelp-a source of elevated urinary arsenic. Clin Toxicol 8(3):325–331

    Article  CAS  Google Scholar 

  • Wang L, Zhou GB, Liu P, Song J-H, Liang Y, Yan X-J, Xu F, Wang B-S, Mao J-H, Shen Z-X, Chen SJ, Chen Z (2008) Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci 105(12):4826–4831

    Article  CAS  Google Scholar 

  • Wegener T (2017) Patterns and trends in the use of herbal products, herbal medicine and herbal medicinal products. Int J Complement Altern Med 9(6):00317

    Article  Google Scholar 

  • WHO (1988) Derived intervention levels for radionuclides in food: guidelines for application after widespread radioactive contamination resulting from a major radiation accident. Geneva: World Health Organization. Available at http://www.who.int/iris/handle/10665/40421. Accessed 4Apr18

  • WHO (2000) General guidelines for methodologies on research and evaluation of traditional medicine. WHO/EDM/TRM/2000.1. Accessed 4April18

  • WHO (2002) Traditional medicine strategy 2002–2005. World Health Organization, Geneva 74 pp. WHO/EDM/TRM/2002. Accessed 11Mar19

    Google Scholar 

  • WHO (2003) Traditional medicine. Fifty-sixth world health assembly A56/18. Fact sheet number 134. Geneva: WHO. Accessed 4 April18

  • WHO (2005) National policy on traditional medicine and regulation of herbal medicines - report of a WHO Global Survey, p. 168

  • WHO (2007) WHO guidelines for assessing the quality of herbal medicines with reference to contaminants and residues. WHO Press, World Health Organization, Geneva 118 pp

    Google Scholar 

  • WHO (2012) The regional strategy for traditional medicine in the Western Pacific (2011–2020). WHO Regional Office for the Western Pacific, Manila 71 pp

    Google Scholar 

  • WHO (2013) WHO traditional medicine strategy: 2014–2023. World Health Organisation, Geneva 76 pp

    Google Scholar 

  • WHO (2017) Guidelines on good herbal processing practices (GHPP). World Health Organisation, Geneva, 60 pp

    Google Scholar 

  • WHO (2018) Expert Committee on Specifications for Pharmaceutical Preparations, fifty-second report: WHO Technical Report Series, No. 1010, 424 pp.

  • Wong S, Chan H, Teo S (1998) The spectrum of cutaneous and internal malignancies in chronic arsenic toxicity. Singap Med J 39(4):171–173

    CAS  Google Scholar 

  • Xue CC, Zhang AL, Lin V, Da Costa C, Story DF (2007) Complementary and alternative medicine use in Australia: a national population-based survey. J Altern Complement Med 13(6):643–650

    Article  Google Scholar 

  • Yee SK, Chu SS, Xu YM, Choo PL (2005) Regulatory control of Chinese proprietary medicines in Singapore. Health Policy 71(2):133–149

    Article  Google Scholar 

  • Yu E, Yeung C (1987) Lead encephalopathy due to herbal medicine. Chin Med J 100(11):915–917

    CAS  Google Scholar 

  • Zeisel SH (1999) Regulation of “nutraceuticals”. Science 285(5435):853–1855

    Article  Google Scholar 

  • Zhang J, Wider B, Shang H, Li X, Ernst E (2012) Quality of herbal medicines: challenges and solutions. Complement Ther Med 20(1–2):100–106

    Article  Google Scholar 

  • Ziegler PJ, Nelson JA, Jonnalagadda SS (2003) Use of dietary supplements by elite figure skaters. Int J Sports Nutr Exerc Metab 13(3):266–276

    Article  CAS  Google Scholar 

Download references

Funding

The author received financial support from Macquarie University through an International Macquarie Research Training Program Scholarship (iMQRTP) and the Ghana Atomic Energy Commission for a study leave grant.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eva T. Gyamfi.

Additional information

Responsible editor: Philippe Garrigues

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

(DOCX 129 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gyamfi, E.T. Metals and metalloids in traditional medicines (Ayurvedic medicines, nutraceuticals and traditional Chinese medicines). Environ Sci Pollut Res 26, 15767–15778 (2019). https://doi.org/10.1007/s11356-019-05023-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-019-05023-2

Keywords

Navigation