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Ameliorative effect of synthetic γ-aminobutyric acid (GABA) on performance traits, antioxidant status and immune response in broiler exposed to cyclic heat stress

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Abstract

The aim of this study was to find the effect of synthetic γ-aminobutyric acid (GABA) on the performance, antioxidant status, and immune response in broiler exposed to summer stress. A total of 400-day-old male broiler chickens (Ross 308) was randomly distributed into five treatments (5 replicates). One group served as a control (basal diet only) while the others were supplemented with GABA at the rate of 25 (GABA-25), 50 (GABA 50), 75 (GABA-75), and 100 (GABA-100) mg/kg feed. The experiment was continued for 35 days. Feed intake during the third week was significantly higher (P < 0.05) in GABA-75 and GABA-100, however, it increased significantly (P < 0.05) in GABA-100 during the fourth and fifth week. Overall mean feed intake was significantly (P < 0.05) high in GABA-75 and GABA-100. From the results, we found that body weight improved significantly (P < 0.05) in GABA-50 in week-3. During the fourth, fifth, and overall, body weight increased significantly (P < 0.05) in GABA-100. Significantly, high (P < 0.05) feed conversion ratio (FCR) was found in GABA-100 during the third, fourth, fifth, and on an overall basis. Mean Malondialdehyde (MDA) decreased significantly (P < 0.05) in GABA-100 while Paraoxonase (PON1) and Newcastle disease (ND) titer increased significantly (P < 0.05) in the same group. We concluded that performance traits, antioxidant status, and immune response improved in broiler supplemented 100 mg/kg GABA, exposed to cyclic heat stress.

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Acknowledgments

The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for supporting this work through research group No RG-1436-021.

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Authors and Affiliations

  1. Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan

    Naila Chand, Sher Muhammad, Rifat Ullah Khan & Zia ur Rehman

  2. Department of Animal production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh, 11451, Saudi Arabia

    Rifat Ullah Khan & Ibrahim Abdullah Alhidary

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  1. Naila Chand
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  2. Sher Muhammad
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  3. Rifat Ullah Khan
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  4. Ibrahim Abdullah Alhidary
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  5. Zia ur Rehman
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Correspondence to Rifat Ullah Khan.

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Responsible editor: Philippe Garrigues

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Chand, N., Muhammad, S., Khan, R.U. et al. Ameliorative effect of synthetic γ-aminobutyric acid (GABA) on performance traits, antioxidant status and immune response in broiler exposed to cyclic heat stress. Environ Sci Pollut Res 23, 23930–23935 (2016). https://doi.org/10.1007/s11356-016-7604-2

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