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Concurrent training is able to increase the activity of adenosine deaminase in platelets in young women

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Abstract

Background

Sedentary lifestyle habits are directly related to the increase in the production of reactive oxygen species, to provide a chronic state of oxidative stress. Furthermore, the purinergic system is involved in extracellular signaling and thus influences pathological and physiological processes. Thus, physical exercise is responsible for triggering molecular and tissue changes, to condition the body’s pathophysiological processes, being often suggested as a form of non-pharmacological treatment in different health conditions.

Aim

To evaluate the effect of physical exercise on markers of oxidative stress and the purinergic system in young adults.

Method

Sixteen women students, aged between 20 and 40 years, were submitted to the physical exercise protocol, both aerobic and resistance (concurrent training) during the period of eight weeks, making a total of 20 h of training.

Results

Our findings showed that physical exercise was responsible for increasing the hydrolysis of adenosine diphosphate (ADP) (p = 0.001) and adenosine deaminase (ADA) (p = 0.041) in platelets, indicating an increase in ecto-nucleoside triphosphate diphosphohydrolase (ecto-NTPDase) after eight weeks of physical exercise. Furthermore, there was an increase in the concentration of thiobarbituric acid reactive substances (TBARS) (p = 0.012) and protein thiols (PSH) (p = 0.004) after one week of exercise. Furthermore, it can be considered that resistance exercise can stimulate the antioxidant defense mechanisms as well as promote an anti-inflammatory and anti-platelet aggregation state.

Conclusion

In conclusion, physical exercise alters both the mechanisms of oxidative stress and the purinergic system, to have the potential to attenuate inflammatory mechanisms.

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Availability of data and material

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Medicine, Federal University of Fronteira Sul (UFFS), Chapecó, Santa Catarina-SC, Brazil

    Matheus Ribeiro Bizuti & Eduardo de Camargo Schwede

  2. Department of Nursing, Federal University of Fronteira Sul (UFFS), Chapecó, Santa Catarina-SC, Brazil

    Fabiana Brum Haag

  3. Department of Biochemistry, Federal University of Fronteira Sul (UFFS), Chapecó, Santa Catarina-SC, Brazil

    Filomena Marafon & Beatriz da Silva Rosa Bonadiman

  4. Department of Graduate Studies in Biomedical Sciences, Federal University of Fronteira Sul (UFFS), Fronteira Sul, Highway SC 484 - Km 02, Chapecó, Santa Catarina-SC, Zipcode 89815-899, Brazil

    Margarete Dulce Bagatini & Débora Tavares de Resende e Silva

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  1. Matheus Ribeiro Bizuti
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  2. Eduardo de Camargo Schwede
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  3. Fabiana Brum Haag
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  6. Margarete Dulce Bagatini
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  7. Débora Tavares de Resende e Silva
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Contributions

Conceptualization: MRB, FBG and DTReS; Methodology: ECS, FM, BSRB and MDB; Formal analysis and investigation: MRB and FBH; Writing–preparation of the original sketch: MRB and ECS; Writing–revision and editing: MRB and DTReS.

Corresponding author

Correspondence to Débora Tavares de Resende e Silva.

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All procedures were approved by the Research Ethics Committee (CEP) of the Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology and was registered through Brazil Platform under CAAE: 85407018.3.0000.5333. Participants were informed about the purpose of the research and about the methods used for data collection and intervention, as well as their evaluation. Finally, all the requirements of the law were followed to maintain the respect, dignity and freedom of the participants.

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Bizuti, M.R., de Camargo Schwede, E., Haag, F.B. et al. Concurrent training is able to increase the activity of adenosine deaminase in platelets in young women. Sport Sci Health 19, 849–859 (2023). https://doi.org/10.1007/s11332-022-00970-9

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  • DOI: https://doi.org/10.1007/s11332-022-00970-9

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