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10 km running race induces an elevation in the plasma myokine level of nonprofessional runners

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Abstract

Purpose

Acute and chronic physical exercise is believed to have beneficial effects on human health. Exercise is also able to modulate immune function. We hypothesed that exercise is able to induce many benefits for human health by modulating immune functions through the production and release of many myokines. Here, we investigated the effects of a running race on the level of plasmatic myokines.

Methods

Nine male volunteers took part in this study. Blood samples were obtained before, immediately after and 24 h after the race.

Results

Participants completed the 10 km running race in 49.85 ± 7.04 min. The levels of IL-6 elevated after exercise (0.94 ± 0.4–2.82 ± 0.3 pg/ml). The IL-15 plasma level was also higher immediately after (0.88 ± 0.25–1.29 ± 0.36 pg/ml), and 24 h after (1.30 ± 1.01 pg/ml), the end of the exercise. Irisin increased only 24 h after exercise (632.60 ± 188.40–974.70 ± 232.30 pg/ml). FABP3 increased after exercise (829.60 ± 68.93–1306.00 ± 319.10 pg/ml). The plasma levels of BDNF (4719.00 ± 701.80–5557.00 ± 810.30 pg/ml) and Fractalkine increased after exercise (101.2 ± 34.96–134.90 ± 43.62 pg/ml). The level of FSTL (7265.00 ± 1553.00–9074.00 ± 1662.00 pg/ml) and Osteonectin (16.52 ± 3.54–15.71 ± 3.38 pg/ml) also increased after exercise, and then returned to baseline level 24 h after the end of the session.

Conclusion

Taken together, these results suggest that a 10 km running race induces elevation of important myokine plasma levels.

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Authors and Affiliations

  1. Laboratório de Inflamação e Imunologia do Exercício (LABIIEX), Escola de Educação Física (EEF-UFOP), Campus Morro do Cruzeiro s/n, Ouro Preto, MG, CEP 35400-000, Brazil

    Lucas Soares Marcucci-Barbosa, Francisco Martins-Junior, Lázaro Fernandes Lobo, Mariana Gomes Morais & Albená Nunes-Silva

  2. Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Belo Horizonte, MG, CEP 30130-1000, Brazil

    Janaina Matos Moreira & Erica Leandro Marciano Vieira

  3. Laboratório de ImunoFarmacologia, Instituto de Ciências Biológicas (ICB), Bloco O4, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, CEP 30130-1000, Brazil

    Mariana Gomes Morais

  4. Belo Horizonte, Brazil

    Albená Nunes-Silva

Authors
  1. Lucas Soares Marcucci-Barbosa
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  2. Francisco Martins-Junior
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  3. Lázaro Fernandes Lobo
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  4. Mariana Gomes Morais
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  5. Janaina Matos Moreira
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  6. Erica Leandro Marciano Vieira
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  7. Albená Nunes-Silva
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Corresponding author

Correspondence to Albená Nunes-Silva.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Santa Casa Hospital in Belo Horizonte, MG, Brazil (466/2012) n. 074/2007.) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Written informed consent was obtained from all individual participants included in the study.

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Marcucci-Barbosa, L.S., Martins-Junior, F., Lobo, L.F. et al. 10 km running race induces an elevation in the plasma myokine level of nonprofessional runners . Sport Sci Health 16, 313–321 (2020). https://doi.org/10.1007/s11332-019-00608-3

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  • DOI: https://doi.org/10.1007/s11332-019-00608-3

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