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Effect of house dust mite allergen on sleep parameters and sleep quality

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

The role of nasal problems such as allergic rhinitis in the development of obstructive sleep apnea (OSA) is controversial. The purpose of this study was to analyze the effects of house dust mite (HDM) allergen on sleep-related problems.

Methods

In a retrospective study patients were classified according to the house dust mite (HDM)-related specific immunoglobulin E (IgE) level into a low HDM-IgE group (group A) and a high HDM-IgE group (group B). Polysomnographic indices, OSA severity, and self-administered questionnaire results were compared between groups. Correlational analysis was used to identify associations between specific IgE values and sleep parameters related to respiratory events.

Results

A total of 327 patients were enrolled. N1 stage ratio, apnea index, and apnea–hypopnea index were significantly higher in group B (P = 0.010, 0.003, and 0.002 respectively) than in group A. N2 stage ratio, and lowest and mean oxygen saturation were significantly lower in group B (P = 0.001, 0.001, and < 0.001 respectively). After propensity score matching, the apnea index and lowest and mean oxygen saturation remained significantly different (P = 0.005, 0.005, and 0.001 respectively). Patients in group B were more likely to have severe OSA and worse subjective sleep quality. In correlational analysis, lowest and mean oxygen saturation were significantly negatively correlated with specific IgE values.

Conclusion

A high HDM-specific IgE level was associated with the occurrence of respiratory events and oxygen desaturation during sleep, and with the presence of severe OSA, as well as poorer subjective sleep quality.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors thank Dr. Yun-Jung Yang (Catholic Kwandong University) for help with the statistical analysis.

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Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-Ro, Bupyeong-Gu, Incheon, 21431, Republic of Korea

    Yeon Hee Im, Dong-Hyun Kim, Eun-Ju Jeon, Inn-Chul Nam, Hyun Jin Lee, Kwi Ju Yu & Dae-Yang Kim

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Contributions

All of the authors contributed to the preparation of the manuscript, and every individual fulfills the authorship criteria. Conceptualization of the study was done by Yeon Hee Im, Dong-Hyun Kim, Kwi Ju Yu, and Dae-Yang Kim. Data collection and statistical analysis were performed by Dong-Hyun Kim, Eun-Ju Jeon, Inn-Chul Nam, and Hyun Jin Lee. The original draft of the manuscript was written by Yeon Hee Im. All authors participated in the revision of the manuscript, read the final version of the manuscript and agreed to the submission.

Corresponding author

Correspondence to Dong-Hyun Kim.

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Ethics approval

This study is a retrospective analysis based on medical records, and the consent process was exempted.

Informed consent

The Institutional Review Board of the Incheon St. Mary’s Hospital approved this study (IRB No. OC22RASI0070). The study was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments.

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The authors declare no competing interests.

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Im, Y.H., Kim, DH., Jeon, EJ. et al. Effect of house dust mite allergen on sleep parameters and sleep quality. Sleep Breath 27, 2231–2239 (2023). https://doi.org/10.1007/s11325-023-02832-1

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  • DOI: https://doi.org/10.1007/s11325-023-02832-1

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