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ApEn for assessing hypoxemia severity in obstructive sleep apnea hypopnea syndrome patients

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Objective

A new index, approximate entropy (ApEn) of oxygen saturation, was used to assess the severity of hypoxemia in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), determine the correlation with other parameters, and explore its clinical value.

Methods

A retrospective analysis was performed on 1200 patients with OSAHS and snorers (normal control). All subjects underwent sleep apnea monitoring for 6 h. Subjects were divided into four subgroups by apnea-hypopnea index (AHI): normal control (AHI < 5), mild OSAHS (5 ≤ AHI < 15), moderate OSAHS (15 ≤ AHI < 30), and severe OSAHS 104 (AHI ≥ 30). ApEn was initially compared among the subgroups. Then a correlation analysis of AHI with ApEn and a correlation analysis of ApEn with oxygen desaturation index (ODI), lowest oxygen saturation (LO2), and T < 90% were performed. (2) The AHI was used as the gold standard, and an attempt was performed to determine the value of ApEn to assess the severity of hypoxemia in OSAHS.

Results

Among the 1200 subjects, 822 subjects were men (72%) and mean age was 53.2 ± 15.2 years (range 24–95 years). The ApEn in each group was significantly different (P <0.001), and the ApEn synchronously increased with AHI. Furthermore, a significant difference in ApEn was found among the groups (P <0.001). In addition, ApEn had a good correlation with ODI, LO2, and T <90%. According to the ROC analysis results, the boundary value of ApEn to judge OSAHS patients with mild, moderate, and severe hypoxia was 16.72, 17.84, and 20.06, respectively.

Conclusion

ApEn synchronously increased with the AHI and had a good correlation with AHI, ODI, LO2, and T <90%. These findings suggest that ApEn may have clinical value for assessing hypoxia severity in OSAHS patients.

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Authors and Affiliations

  1. Department of health management department, Peking Union Medical College Hospital, Beijing, 100730, China

    Jie Liu & Songbai Lin

  2. Department of Respiratory, Peking Union Medical College Hospital, Beijing, 100730, China

    Rong Huang & Yi Xiao

Authors
  1. Jie Liu
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  2. Rong Huang
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  3. Yi Xiao
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  4. Songbai Lin
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Correspondence to Songbai Lin.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Peking Union Medical College Hospital committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Liu, J., Huang, R., Xiao, Y. et al. ApEn for assessing hypoxemia severity in obstructive sleep apnea hypopnea syndrome patients. Sleep Breath 24, 1481–1486 (2020). https://doi.org/10.1007/s11325-019-02004-0

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  • DOI: https://doi.org/10.1007/s11325-019-02004-0

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