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Physiological correlates to spontaneous physical activity variability in obese patients with already treated sleep apnea syndrome

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Background/objectives

Physical activity is promoted in patients with sleep disorders and obesity. The aim of the present study was to assess physiological factors influencing objectively measured spontaneous physical activity in already treated patients for obstructive sleep apnea (OSA) by nocturnal continuous positive airway pressure (CPAP).

Subjects/methods

Fifty-five patients (age = 53 ± 3 years; body mass index (BMI) = 38 ± 3 kg/m2; compliance with CPAP >4 h/night) were prospectively included. Measurements were 5-day actigraphy with metabolic equivalent of task (METs) assessment, body composition, pulmonary function, quadriceps and respiratory muscle strength, exercise capacity (6-min walking distance and maximal aerobic capacity), as well as sleep parameters (sleepiness, duration, oxygen saturation, and micro-arousals during sleep) and quality of life (SF-36 questionnaire).

Results

As expected, the number of steps per day (6879 ± 2511) and mean intensity of physical activity (1.38 ± 0.15 METs) were below the recommendations for obese population. In age-adjusted stepwise regression models, peak oxygen consumption (VO2 peak) and peak dyspnea perception during incremental exercise test were independent predictors of the number of steps per day (r = 0.49, p = 0.001) although VO2 peak and peak minute ventilation were independent predictors of intensity of physical activity (in METs/day; r = 0.49, p = 0.001).

Conclusions

In severe obese patients with OSA, exercise capacity, ventilatory requirement, and dyspnea perception were main physiological components of physical activity. These results emphasize the need to consider specific training interventions that increase ability to perform intense physical activity in obese OSA.

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Authors and Affiliations

  1. HP2 Laboratory, Grenoble Alps University, 38000, Grenoble, France

    Isabelle Vivodtzev, Monique Mendelson, Bernard Wuyam, Renaud Tamisier, Patrick Lévy & Jean-Louis Pépin

  2. Inserm U1042, 38000, Grenoble, France

    Isabelle Vivodtzev, Monique Mendelson, Bernard Wuyam, Renaud Tamisier, Patrick Lévy & Jean-Louis Pépin

  3. Cardio-Respiratory Functional Exploration and Sleep Laboratory, CHU Grenoble, 38000, Grenoble, France

    Isabelle Vivodtzev, Monique Mendelson, Bernard Wuyam, Renaud Tamisier, Patrick Lévy & Jean-Louis Pépin

  4. Centre de recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval, G1V4G5, Québec, Canada

    Isabelle Vivodtzev, Marilie Croteau & François Maltais

  5. Agiradom, 38240, Meylan, France

    Sandy Gorain

Authors
  1. Isabelle Vivodtzev
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  2. Monique Mendelson
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  3. Marilie Croteau
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  4. Sandy Gorain
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  5. Bernard Wuyam
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  6. Renaud Tamisier
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  7. Patrick Lévy
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  8. François Maltais
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  9. Jean-Louis Pépin
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Corresponding author

Correspondence to Isabelle Vivodtzev.

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Funding

Foundation Agir Pour les Maladies Chroniques (APMC), Meylan, France, and Philips Respironics, France, provided financial support in the form of grant funding. The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Vivodtzev, I., Mendelson, M., Croteau, M. et al. Physiological correlates to spontaneous physical activity variability in obese patients with already treated sleep apnea syndrome. Sleep Breath 21, 61–68 (2017). https://doi.org/10.1007/s11325-016-1368-2

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  • DOI: https://doi.org/10.1007/s11325-016-1368-2

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