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Diffusion-weighted magnetic resonance imaging of mandibular bone marrow: do apparent diffusion coefficient values of the cervical vertebrae and mandible correlate with age?

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Abstract

Objectives

The objective of this investigation was to assess the correlation between the mandible and cervical vertebrae bone marrow apparent diffusion coefficient (ADC), obtained by diffusion-weighted magnetic resonance imaging (DWI), with age; to verify the correlation between ADC values from the mandible and the cervical vertebrae; to describe and assess the differences between ADC values obtained from DWI examinations of distinct mandible areas as well as cervical vertebrae.

Methods

Thirty imaging examinations with DWI for that included the mandible and C1, C2, C3, and C4 vertebrae in the same examination were included. ADC values were collected from 7 distinct areas in the mandible and the cervical vertebrae. Differences between ADC values and non-parametric correlations were performed.

Results

A total of 270 regions were assessed. No significant difference was found between ADC values of all areas tested. An inverse correlation was found between C2, C3, and C4 vertebrae ADC values and age.

The significant correlation of anatomic area ADC values and age were presented as graphics to verify if the linear trend of ADC values and age are in accordance with the literature

Conclusions

The mandible area that most correlates with the cervical vertebrae, using ADC values, is the posterior trabecular area, below the inferior molars. Also, C2, C3, and C4 vertebrae ADC values inversely correlate with age, which demonstrates the bone qualitative changes in bone composition. ADC values may be useful for the qualitative assessment of bone quality to screen patients at osteoporosis risk.

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Authors and Affiliations

  1. Department of Stomatology, School of Dentistry, University of São Paulo, 2227 Lineu Prestes Avenue, São Paulo, SP, 05508-000, Brazil

    Luciana Munhoz, Reinaldo Abdala Júnior, Isabela Goulart Gil Choi & Emiko Saito Arita

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  1. Luciana Munhoz
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  2. Reinaldo Abdala Júnior
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  3. Isabela Goulart Gil Choi
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Correspondence to Luciana Munhoz.

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Luciana Munhoz, Isabela Choi, Reinaldo Abdala Junior and Emiko Saito Arita declare no conflict of interest.

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Ethics committee approval was obtained for this study (number 2.441.500), and the guidelines of the Helsinki Declaration were followed in this investigation.

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Munhoz, L., Abdala Júnior, R., Choi, I.G.G. et al. Diffusion-weighted magnetic resonance imaging of mandibular bone marrow: do apparent diffusion coefficient values of the cervical vertebrae and mandible correlate with age?. Oral Radiol 38, 72–79 (2022). https://doi.org/10.1007/s11282-021-00528-4

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