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Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen

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Abstract

Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC is a slow-growing tumor characterized by perineural invasion and often has a high-recurrence rate. We describe a case of oropharyngeal ACC invading the mandibular bone through the mandibular foramen that showed a rare pattern of origin and invasion. A 70-year-old woman complained of noise and pain around the right temporomandibular joint. Osteomyelitis was suspected on the initial imaging examinations, although the findings were slightly atypical. However, a mass was observed in the right oropharyngeal wall on subsequent imaging examinations, and mandibular bone invasion, rather than osteomyelitis, was additionally suspected. The mass in the right oropharyngeal wall and right mandible was surgically excised. On postoperative histopathological examination, the mass was finally diagnosed as ACC. As tumor cells were also observed around the inferior alveolar nerve, mandibular bone invasion through the mandibular foramen was suspected. An oropharyngeal ACC invading the mandibular bone through the mandibular foramen is extremely rare. The present case suggests that bone invasion should be considered carefully with several imaging examinations when a malignant tumor such as ACC is observed around the jaw bone.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Yohei Takeshita & Junichi Asaumi

  2. Department of Oral Diagnosis and Dentomaxillofacial Radiology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Shunsuke Okada, Miki Hisatomi, Hidenobu Matsuzaki, Jun Murakami & Junichi Asaumi

  3. Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Hotaka Kawai & Hitoshi Nagatsuka

  4. Department of Otorhinolaryngology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Yohei Noda

  5. Dental Comprehensive Diagnosis Room, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Mariko Fujita & Junichi Asaumi

  6. Department of Dental Informatics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Yoshinobu Yanagi

Authors
  1. Yohei Takeshita
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  2. Shunsuke Okada
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  3. Miki Hisatomi
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  4. Hidenobu Matsuzaki
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  5. Hotaka Kawai
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  6. Yohei Noda
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  7. Jun Murakami
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  8. Mariko Fujita
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  9. Hitoshi Nagatsuka
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  10. Yoshinobu Yanagi
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  11. Junichi Asaumi
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Corresponding author

Correspondence to Yoshinobu Yanagi.

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Conflict of interest

Takeshita Y, Okada S, Hisatomi M, Matsuzaki H, Kawai H, Noda Y, Murakami J, Fujita M, Nagatsuka H, Yanagi Y, Asaumi J declare that they have no conflict of interest.

Ethical approval

We obtained consent from the patients in this case report. This case report was approved by Okayama University ethics committee (No. 1807-005).

Human rights statements

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.

Informed consent

The patients provided informed consent for this case report.

Animal rights statements

This article does not contain any studies with animal subjects performed by any of the authors.

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Takeshita, Y., Okada, S., Hisatomi, M. et al. Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen. Oral Radiol 35, 335–340 (2019). https://doi.org/10.1007/s11282-018-0359-3

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  • DOI: https://doi.org/10.1007/s11282-018-0359-3

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