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The pattern of viral persistence in monkeys intra-tracheally infected with Simian varicella virus

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Abstract

In situ PCR (ISPCR) and in situ hybridisation (ISH) was performed on 32 tissues from 10 monkeys, intra-tracheally (IT) infected with simian varicella virus (SVV) and 5 tissues from 3 uninfected control animals. The results showed persistence of SVV DNA up to 2 years post-infection (pi) and the localisation of SVV to be confined to neurons except at time points 9 and 10 months pi where SVV positive satellite cells were also detected. There was no evidence for transcription of SVV ORFs 63 and 21 in the ganglia of the one IT infected and 2 naturally infected monkeys investigated using RNA ISH.

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Acknowledgements

We thank Drs Ravi Mahalingam and Donald Gilden for generously providing the SVV tissues for this study, and for helpful discussions. This work was supported in part by a grant from the Wellcome Trust to PGEK.

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  1. Department of Neurology, Institute of Neurological Sciences, University of Glasgow, Southern General Hospital, 1345 Govan Road, Glasgow, Scotland, G51 4TF, UK

    Esther Grinfeld & Peter G. E. Kennedy

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  1. Esther Grinfeld
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  2. Peter G. E. Kennedy
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Correspondence to Peter G. E. Kennedy.

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Grinfeld, E., Kennedy, P.G. The pattern of viral persistence in monkeys intra-tracheally infected with Simian varicella virus. Virus Genes 35, 289–292 (2007). https://doi.org/10.1007/s11262-007-0077-0

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  • DOI: https://doi.org/10.1007/s11262-007-0077-0

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