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Methylamine induced hypophagia is mediated via dopamine D1 and D2 receptors in neonatal meat chicks

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Abstract

Recently, methylamine has been found as an endogenous amine, which is controling food intake in mammals. However, there is no evidence about the effect of methylamine on feeding behavior in poultry. So, the present study was designed to evaluate the effect of intracerebroventricular (ICV) injection of methylamine and involvement of central methylamine/dopaminergic systems on feeding behavior in neonatal meat type chicks. In experiment 1, chicks were ICV injected with different doses of methylamine (0.48, 0.96, 1.44, 1.92 and 2.40 μmol). In experiment 2, chicks received a dose of either the control solution, 2.40 μmol methylamine, 125 nmol L-DOPA (dopamine precursor) or a combination of methylamine plus L-DOPA. Experiments 3–7 were similar to experiment 2 except that 150 nmol 6-OHDA (dopamine synthase inhibitor), 5 nmol SCH23390 (D1 receptor antagonist), 5 nmol AMI-193 (D2 receptor antagonist), 6.4 nmol NGB2904 (D3 receptor antagonist) and 6 nmol L-741, 742 (D4 receptor antagonist) were used instead of 125 nmol L-DOPA, respectively. Cumulative food intake was determined until 2 h post-injection. According to the results, methylamine significantly decreased food intake in a dose dependent manner (p < 0.05). The inhibitory effect of methylamine on food intake was significantly attenuated by 6-OHDA, SCH23390 and AMI-193 (P < 0.05), but NGB2904 and L-741, 742 had no effect on food intake induced by methylamine. In addition, hypophagic effect of methylamine significantly amplified by L-DOPA (P < 0.05). These results suggest that methylamine decrease food intake and there is an interaction between methylamine and dopaminergic system via D1 and D2 receptors in chickens.

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Acknowledgments

This research was performed in the Dr. Rastegar central Lab, Faculty of Veterinary Medicine, University of Tehran, Iran.

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Authors and Affiliations

  1. Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mansour Mahzouni

  2. Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, 14155-6453, Iran

    Morteza Zendehdel & Vahab Babapour

  3. Section of Poultry, Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Saeed Charkhkar

Authors
  1. Mansour Mahzouni
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  2. Morteza Zendehdel
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  3. Vahab Babapour
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  4. Saeed Charkhkar
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Correspondence to Morteza Zendehdel.

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This manuscript does not contain any studies with human subjects performed by any of the authors.

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All experiments executed according to the Guide for the Care and Use of Laboratory Animals and approved by the institutional animal ethics committee.

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Mahzouni, M., Zendehdel, M., Babapour, V. et al. Methylamine induced hypophagia is mediated via dopamine D1 and D2 receptors in neonatal meat chicks. Vet Res Commun 40, 21–27 (2016). https://doi.org/10.1007/s11259-015-9649-y

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  • DOI: https://doi.org/10.1007/s11259-015-9649-y

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