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Role of cannabinoidergic system on food intake in neonatal layer-type chicken

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Abstract

Central regulatory mechanisms for neurotransmitters of food intake vary among animals. Endocannabinoids have crucial role on central food intake regulation in mammals but its role has not been studied in layer-type chicken. Thus, in this study 6 experiments designed to evaluate effects of intracerebroventricular (ICV) administration of 2-AG (2-Arachidonoylglycerol, selective CB1 receptors agonist), SR141716A (selective CB1 receptors antagonist), JWH015 (selective CB2 receptors agonist), AM630 (selective CB2 receptors antagonist) on feeding behavior in 3 h food deprived neonatal layer-type chickens. In experiment 1, birds ICV injected with control solution and 2-AG (0.25, 0.5 and 1 μg). In experiment 2: control solution, SR141716A (6.25, 12.5 and 25 μg) were ICV injected to birds. In experiment 3 animals received: control solution, SR141716A (6.25 μg), 2-AG (1 μg) and co-injection of SR141716A+2-AG. In experiment 4, chickens received control solution and JWH015 (6.25, 12.5 and 25 μg). In experiment 5, control solution and AM630 (1.25, 2.5 and 5 μg) were injected. In experiment 6, the birds received control solution, AM630 (1.25 μg), JWH015 (25 μg) and co-administration of AM630+JWH015. Then, cumulative food intake was recorded until 120 min after injection. According to the results, 2-AG dose dependently increased cumulative food intake while SR141716A reduced appetite compared to control group (P < 0.05). Injection of 2-AG (1 μg) amplified food intake and its effect minimized by SR141716A (6.25 μg) (P < 0.05). Also, ICV injection of JWH015 (25 μg) dose dependently increased food intake and co-injection of JWH015+AM630 decreased JWH015-induced food intake (P < 0.05). These results suggest CB1 and CB2 receptors have an important role on ingestive behavior in FD3 neonatal layer-type chicken.

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Conflict of interest

Abbas Alizadeh, Morteza Zendehdel, Vahab Babapour, Saeed Charkhkar and Shahin Hassanpour declare that they have no conflict of interest.

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This manuscript does not contain any studies with human subjects performed by any of the authors.

Human and animal rights

All experiments executed according to the Guide for the Care and Use of Laboratory Animals and approved by the institutional animal ethics committee.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Abbas Alizadeh, Saeed Charkhkar & Shahin Hassanpour

  2. Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, PO Box: 14155-6453, Tehran, Iran

    Morteza Zendehdel & Vahab Babapour

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  1. Abbas Alizadeh
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  2. Morteza Zendehdel
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Correspondence to Morteza Zendehdel.

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Alizadeh, A., Zendehdel, M., Babapour, V. et al. Role of cannabinoidergic system on food intake in neonatal layer-type chicken. Vet Res Commun 39, 151–157 (2015). https://doi.org/10.1007/s11259-015-9636-3

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  • DOI: https://doi.org/10.1007/s11259-015-9636-3

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