Abstract
Purpose
The goal of this study was to externally validate the recently proposed prognostic model for the prediction of estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 1 year after living donor nephrectomy.
Methods
130 living kidney donors (median age at donation 52.3 years, range 24.7–75.6 years) were investigated before and after donation between March 2000 and April 2016. Preoperative eGFR values varied between 61.7 and 148.4 ml/min (mean: 89, median: 88). Observed eGFR 1 year after transplantation (±45 days) ranged between 36.3 and 97.1 ml/min (mean: 55, median: 53). 70.8% of donors displayed eGFR values < 60 ml/min 1 year after donation. Predicted eGFR 1 year after donation was determined using the prognostic model proposed by Benoit et al. (Int Urol Nephrol 49(5):793–801. doi:10.1007/s11255-017-1559-1, 2017): postoperative eGFR ml/min/1.73 m2 = 31.71 + (0.521 × eGFR in ml/min prior to donation −0.314 × Age in years at donation). Pearson correlation and receiver operating characteristics curve (ROC-curve) were used to assess external validity of the proposed prognostic model to predict postoperative eGFR in ml/min and eGFR < 60 ml/min.
Results
The correlation between predicted and observed eGFR 1 year after donation was significant (p < 0.001; R 2 = 0.594). The area under the ROC-curve (AUROC) demonstrated a high sensitivity and specificity for predicted eGFR values < 60 ml/min (AUROC = 0.866).
Conclusions
The proposed prognostic model for the prediction of postoperative eGFR was successfully validated in our cohort. We therefore consider the model as generally applicable.
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Funding
This work was supported by a grant from the German Federal Ministry of Education and Research (reference number: 01EO1302).
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Regarding the patients’ clinical data, as an observational retrospective study, according to the Professional Code of the German Medical Association (article B.III. § 15.1), neither informed consent nor approval of the ethics committee was needed for this study.
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Kulik, U., Gwiasda, J., Oldhafer, F. et al. External validation of a proposed prognostic model for the prediction of 1-year postoperative eGFR after living donor nephrectomy. Int Urol Nephrol 49, 1937–1940 (2017). https://doi.org/10.1007/s11255-017-1683-y
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DOI: https://doi.org/10.1007/s11255-017-1683-y