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Role of ultrasonographic chronic kidney disease score in the assessment of chronic kidney disease

  • Nephrology - Original Paper
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Abstract

Purpose

Ultrasonography (US) is an inexpensive, noninvasive and easy imaging procedure to comment on the kidney disease. Data are limited about the relation between estimated glomerular filtration rate (e-GFR) and all 3 renal US parameters, including kidney length, parenchymal thickness and parenchymal echogenicity, in chronic kidney disease (CKD). In this study, we aimed to investigate the association between e-GFR and ultrasonographic CKD score calculated via these ultrasonographic parameters.

Methods

One hundred and twenty patients with stage 1–5 CKD were enrolled in this study. The glomerular filtration rate was estimated by the Chronic Kidney Disease Epidemiology Collaboration equation. US was performed by the same radiologist who was blinded to patients’ histories and laboratory results. US parameters including kidney length, parenchymal thickness and parenchymal echogenicity were obtained from both kidneys. All 3 parameters were scored for each kidney, separately. The sum of the average scores of these parameters was used to calculate ultrasonographic CKD score.

Results

The mean age of patients was 63.34 ± 14.19 years. Mean kidney length, parenchymal thickness, ultrasonographic CKD score and median parenchymal echogenicity were found as 96.2 ± 12.3, 10.97 ± 2.59 mm, 6.28 ± 2.52 and 1.0 (0–3.5), respectively. e-GFR was positively correlated with kidney length (r = 0.343, p < 0.001), parenchymal thickness (r = 0.37, p < 0.001) and negatively correlated with CKD score (r = −0.587, p < 0.001) and parenchymal echogenicity (r = −0.683, p < 0.001). Receiver operating characteristic curve analysis for distinction of e-GFR lower than 60 mL/min showed that the ultrasonographic CKD score higher than 4.75 was the best parameter with the sensitivity of 81% and positive predictivity of 92% (AUC, 0.829; 95% CI, 0.74–0.92; p < 0.001).

Conclusion

We found correlation between e-GFR and ultrasonographic CKD score via using all ultrasonographic parameters. Also, our study showed that ultrasonographic CKD score can be useful for distinction of CKD stage 3–5 from stage 1 and 2. We suggested that the ultrasonographic CKD score provided more objective data in the assessment of CKD.

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, School of Medicine, Mustafa Kemal University, 31100, Antakya, Hatay, Turkey

    Mustafa Yaprak & Faruk Turgut

  2. Department of Radiology, Batman Regional State Hospital, Batman, Turkey

    Özgür Çakır

  3. Division of Nephrology, Department of Internal Medicine, School of Medicine, Harran University, Şanlıurfa, Turkey

    Mehmet Nuri Turan

  4. Department of Internal Medicine, Batman Regional State Hospital, Batman, Turkey

    Ramazan Dayanan

  5. Department of Biochemistry, Batman Regional State Hospital, Batman, Turkey

    Selçuk Akın & Elif Değirmen

  6. Division of Medical Oncology, Batman Regional State Hospital, Batman, Turkey

    Mustafa Yıldırım

Authors
  1. Mustafa Yaprak
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  2. Özgür Çakır
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  3. Mehmet Nuri Turan
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  4. Ramazan Dayanan
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  5. Selçuk Akın
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  7. Mustafa Yıldırım
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  8. Faruk Turgut
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Correspondence to Mustafa Yaprak.

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The authors have no conflicts of interest to declare.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Yaprak, M., Çakır, Ö., Turan, M.N. et al. Role of ultrasonographic chronic kidney disease score in the assessment of chronic kidney disease. Int Urol Nephrol 49, 123–131 (2017). https://doi.org/10.1007/s11255-016-1443-4

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  • DOI: https://doi.org/10.1007/s11255-016-1443-4

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