Abstract
Background
Our previous studies demonstrated that 2012 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were inaccurate enough for estimating glomerular filtration rate in elderly Chinese. Thus, this study was constructed to modify these equations.
Methods
A total of 839 subjects (aged ≥60 years) from four hospitals in China between October 2009 and December 2014 were included. A random sample of 674 (80.3 %) subjects was used as a training sample set, and the remaining 165 (19.7 %) subjects as the verification set. The equations were modified using the hill-climbing algorithm.
Results
Compared with the original CKD-EPI equations, the accuracy assessment indexes (bias, precision, accuracy and misclassification) were obviously improved after modification. Bland–Altman analysis also demonstrated that this modification attempt gained success to some extent.
Conclusions
The modified 2012 CKD-EPI equations could be more accurate than the original equations for elderly Chinese individuals.
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Acknowledgments
This work was supported by the grants from the Major State Basic Research Development Program of China 2013CB530803, the National Natural Science Foundation of China H0511-81370843, the Chinese Medical Association of Clinical Medicine Research Special Funds 15020020590, the Innovation of Science and Technology Achievement Transformation Fund of Jiangsu Province BL2012066 and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions JX10231801.
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The authors declare that they have no conflict of interest.
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The study was approved by the ethics committee of The First Affiliated Hospital of Nanjing Medical University and conducted in accordance with the Declaration of Helsinki.
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Fen Li and Xiaohua Pei have contributed equally to this work.
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Li, F., Pei, X., Ye, X. et al. Modification of the 2012 CKD-EPI equations for the elderly Chinese. Int Urol Nephrol 49, 467–473 (2017). https://doi.org/10.1007/s11255-016-1434-5
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DOI: https://doi.org/10.1007/s11255-016-1434-5