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Immunostimulatory and antioxidant effects of supplemental feeding with macroalga Sargassum spp. on goat kids

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Abstract

Algae are a rich source of bioactive compounds and health properties that have been narrowly explored in goat production systems. The aim of this study was to determine the effect of feeding diets supplemented with Sargassum spp. on antioxidant status and immune parameters in goat kids. The diets were as follows: control (basal diet without alga), Sargassum spp. 2.5% (Ss2.5), and Sargassum spp. 5% (S5) fed over a 70-day period. A total of 11 body tissues, intestinal mucus, and blood serum were sampled at necropsy. Protein content, superoxide dismutase (SOD), catalase (CAT), myeloperoxidase (MPO), lysozyme, and anti-protease activities were determined, as well as immunoglobulin A (IgA) and immunoglobulin G (IgG). The results indicated that Sargassum spp. supplementation increased protein content in six tissues. Antioxidant activities (SOD and CAT) and immune-related (lysozyme, MPO, and anti-protease) activities were statistically higher (P < 0.05) in Sargassum spp. groups compared with control in several tissues, intestinal mucus, and serum. Imunoglobulin A levels in intestinal mucus were higher (P < 0.05) in Sargassum spp.-supplemented groups than the control group. In conclusion, diet supplementation of Sargassum spp. improves the antioxidant status and enhances the immune parameters in goats. Sargassum spp. dietary supplementation is proposed as strategy to strengthen antioxidant status and stimulate the immune system, which helps in the control of opportunistic pathogens in goats.

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Acknowledgments

The authors are grateful to Rodolfo Osuna Machado and Alfredo Mayoral for the valuable laboratory and field assistance, to Danielle M. Straatmann from CSU Todos Santos Center for the English revision, and to Diana Fischer for the editorial services.

Funding

This research was supported by CONACYT/Mexico (INFR-2014-01/225924 and PDCPN2014-01/248033).

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Authors and Affiliations

  1. Immunology & Vaccinology Group, Centro de Investigaciones Biológicas del Noroeste, Av. Instituto Politécnico Nacional #195, Col. Playa Palo de Santa Rita, 23096, La Paz, BCS, Mexico

    Carlos Angulo, Luis Chavez-Infante, Martha Reyes-Becerril & Miriam Angulo

  2. Tecnológico Nacional de México/Instituto Tecnológico de La Paz, Boulevard Forjadores 4720, Col. 8 de Octubre Segunda Sección, 23080, La Paz, BCS, Mexico

    Reyna Romero-Geraldo

  3. Laboratorio de Sanidad Animal, Universidad Autónoma de Baja California Sur, Carretera al Sur Km 5.5, 23080, La Paz, BCS, Mexico

    Ximena Llinas-Cervantes & Ramón Cepeda-Palacios

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  1. Carlos Angulo
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  2. Luis Chavez-Infante
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  3. Martha Reyes-Becerril
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  4. Miriam Angulo
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Correspondence to Carlos Angulo or Ramón Cepeda-Palacios.

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The experiment was conducted in agreement with the local Bioethical Guidelines of UABCS and Baja California Sur State regulations to avoid causing unnecessary discomfort to experimental animals.

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Angulo, C., Chavez-Infante, L., Reyes-Becerril, M. et al. Immunostimulatory and antioxidant effects of supplemental feeding with macroalga Sargassum spp. on goat kids. Trop Anim Health Prod 52, 2023–2033 (2020). https://doi.org/10.1007/s11250-020-02218-5

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