Abstract
Twelve screened cases of bovine respiratory disease (BRD) in calves were enrolled. Six of the calves were treated intramuscularly with sodium ceftiofur (1 mg/kg), and six were treated with nebulised sodium ceftiofur (1 mg/kg). Comparative evaluation of the two therapeutic modalities was based on repetitive analysis of hematological profile of calves on days 0, 5, and 10 post-therapy. The mortality rate in the group of calves treated with the nebulised sodium ceftiofur was significantly (p < 0.001) lower, and their clinical and hematological parameters returned to normal significantly (p < 0.001) faster than in calves treated intramuscularly. Nebulisation of sodium ceftiofur is the most effective treatment in calves with BRD under field conditions. Nasal lavage fluid analysis indicating a high rise of neutrophil count and macrophages may be used as an alternative method to detect pulmonary inflammation in BRD-affected calves.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Almujalli, A. M., El-Deeb, W. M., Eljalii, E. M., Fouda, T. A., AlBlwy, M., 2015. Clinical, biochemical and bacteriological investigation of pneumonia in calves with special reference to alpha-1-acid glycoprotein response. International Journal of Veterinary Health Sciences and Research, 3, 60–63.
Ayodhya, S., Rao, D. T., Reddy, Y. N., Sundar, N. S. and Kumar, V. G., 2014. Therapeutic management of canine respiratory diseases of bacterial origin with nebulisation and suitable antibiotics in and around Hyderabad city, Andhra Pradesh. International Journal of Advanced Research, 2, 656–62.
Baran, D., De Vuyst, P., Ooms, H. A., 1990. Concentration of tobramycin given by aerosol in the fluid obtained by bronchoalveolar lavage. Respiratory Medicine, 84, 203–04.
Buczinski, S., Forte, G., Francoz, D., Belanger, A. M., 2014. Comparison of thoracic auscultation, clinical score, and ultrasonography as indicators of bovine respiratory disease in preweaned dairy calves. Journal of Veterinary Internal Medicine, 28, 234–42.
Chen, J., Yang, C., Tizioto, P. C., Huang, H., Lee, M. O., Payne, H. R., Lawhon, S. D., Schroeder, F., Taylor, J. F., Womack, J. E., 2016. Expression of the bovine NK-lysin gene family and activity against respiratory pathogens. PloS one, 11, e0158882.
Desmecht, D. J., Linden, A. S., Rollin, F. A., Amory, H., Lekeux, P. M., 1992. Effect of intravenous and aerosol administration of 5-hydroxytryptamine on pulmonary function values in healthy calves. American Journal of Veterinary Research, 3, 315–20.
Fultz, L., Giguere, S., Berghaus, L. J., Grover, G. S., Merritt, D. A., 2015. Pulmonary pharmacokinetics of desfuroylceftiofur acetamide after nebulisation or intramuscular administration of ceftiofur sodium to weanling foals. Equine Veterinary Journal, 47, 473–77.
Hawley, J., Kegley, B., Beck, P., Powell, J., Reynolds, J., Hornsby, P., 2016. Evaluation of antibiotic metaphylactic therapy for receiving calves at risk for bovine respiratory disease. Animal Science Arkansas Animal Science, 50.
Jim, G. K., Booker, C. W., Guichon, P. T., 1992. A comparison of trimethoprim-sulfadoxine and ceftiofur sodium for the treatment of respiratory disease in feedlot calves. The Canadian Veterinary Journal, 33, 245.
McGuirk, S. M., 2008. Disease management of dairy calves and heifers. Veterinary Clinics of North America: Food Animal Practice, 24, 139–53.
Nuytten, J., Muylle, E., Oyaert, W., Van Den Hende, C., 1986. The influence of clenbuterol on prostaglandin F2α-induced dyspnoea in calves. Veterinary Research Communications, 10, 453–46.
Nuytten, J., Muylle, E., Oyaert, W., Van Den Hende, C., 1986. The effect of clenbuterol on lung function parameters in calves suffering from bronchopneumonia. Veterinary Research Communications, 10, 463–46.
O’Connor, A. M., Coetzee, J. F., da Silva, N., Wang, C., 2013. A mixed treatment comparison meta-analysis of antibiotic treatments for bovine respiratory disease. Preventive Veterinary Medicine, 110, 77–87.
Ramadan, A., El-Aty, A. A., 2012. Pharmacokinetics and distribution of florfenicol in bronchial secretions of healthy and Pasteurella multocida infected calves. Pharmaceutica Analytica Acta, 2011.
Rerat, M., Albini, S., Jaquier, V., Hussy, D., 2012. Bovine respiratory disease: Efficacy of different prophylactic treatments in veal calves and antimicrobial resistance of isolated Pasteurellaceae. Preventive Veterinary Medicine, 103, 265–73.
Schaefer, A. L., Cook, N. J., Bench, C., Chabot, J. B., Colyn, J., Liu, T., Okine, E. K., Stewart, M., Webster, J. R., 2012. The non-invasive and automated detection of bovine respiratory disease onset in receiver calves using infrared thermography. Research in Veterinary Science, 93, 928–935.
Sustronck, B., Deprez, P., Muylle, E., Vermeersch, H., Vandenbossche, G., Remon, J. P., 1995. Evaluation of the nebulisation of sodium ceftiofur in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves. Research in Veterinary Science, 59, 267–271.
Toaff-Rosenstein, R. L., Gershwin, L. J., Tucker, C. B., 2016. Fever, feeding, and grooming behavior around peak clinical signs in bovine respiratory disease. Journal of Animal Science, 94, 3918–3932.
Vandermeulen, J., Bahr, C., Johnston, D., Earley, B., Tullo, E., Fontana, I., Guarino, M., Exadaktylos, V., Berckmans, D., 2016. Early recognition of bovine respiratory disease in calves using automated continuous monitoring of cough sounds. Computers and Electronics in Agriculture, 129, 15–26.
Acknowledgements
The authors are highly thankful to the Director, ICAR-Indian Veterinary Research Institute, for providing the necessary research facilities to carry out this work.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
All procedures have been conducted in accordance with the guidelines set out by the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA).
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Joshi, V., Gupta, V.K., Dimri, U. et al. Assessment of nebulisation of sodium ceftiofur in the treatment of calves naturally infected with bovine respiratory disease. Trop Anim Health Prod 49, 497–501 (2017). https://doi.org/10.1007/s11250-016-1219-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11250-016-1219-y