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A systematic review of leptospirosis on dogs, pigs, and horses in Latin America

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Abstract

Leptospirosis is a worldwide zoonosis which can affect many species. Control programs need accurate diagnosis to be successful, and currently, diagnosis relies on serology. It presents three main issues: the sampling, the antigen panel, and the cutoff point. Herein, we propose a systematic review on leptospirosis among dogs, pigs, and horses in Latin America in order to improve the understanding of the seroepidemiology of leptospirosis in these species in the region as well as the temporal development of the research on this topic and, consequently, improve the chances of success on control programs. Internet databases were consulted over 2015. Inclusion criteria included serosurvey using MAT; a relevant number of animals; the presence in the antigen panel of at least one representative of serogroups Icterohaemorrhagiae and Canicola for dogs, Icterohaemorrhagiae, Australis, and Pomona for pigs, and Icterohaemorrhagiae and Australis for horses; and a cutoff point of ≥100. Overall, 240 papers were studied, of which 87 referred to dogs, 66 to pigs, 39 to horses, and 48 to more than one of the studied species. In relation to those that met all the inclusion criteria, it was 45 (66.2%) in dogs, 23 (41.8%) in pigs, and 23 (63.9%) in horses. Leptospirosis is widespread in Latin America. Predominant serogroups are Canicola to dogs and Icterohaemorrhagiae to pigs and horses. Therefore, research on animal leptospirosis should be encouraged in Latin America, in order to reach a greater standardization in studies and then achieve better results on control programs.

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References

  • Adler, B., 2015. Vaccines against leptospirosis. Current Topics in Microbiology and Immunology, 387, 251-272.

    CAS  PubMed  Google Scholar 

  • Adler, B. and De La Peña Moctezuma, A, 2010. Leptospira and leptospirosis. Veterinary Microbiology, 140(3-4), 287-296.

    Article  CAS  PubMed  Google Scholar 

  • Ahmad, S.N., Shah, S. and Ahmad, F.M.H., 2005. Laboratory Diagnosis of leptospirosis. Journal of Postgraduate Medicine, 51(3), 195-200.

    CAS  PubMed  Google Scholar 

  • Athanazio, D.A., Silva, E.F., Santos, C.S., Rocha, G.M., Vannier-Santos, M.A., McBride, A.J.A., Ko, A.I. and Reis, M.G., 2008. Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans. Acta Tropica, 105(2), 176–180.

    Article  PubMed  Google Scholar 

  • Blazius, R.D., Romão, P.R.T., Blazius, E.M.C.G. and da Silva, O.S., 2005. Ocorrência de cães errantes soropositivos para Leptospira spp. na cidade de Itapema, Santa Catarina, Brasil. Cadernos de Saúde Pública, 21(6), 1952-1956.

    Article  PubMed  Google Scholar 

  • Delbem, A.C.B., Freitas J.C., Bracarense A.P.F.R.L., Muller E.E. and Oliveira R.C., 2002. Leptospirosis in slaughtered sows: serological and histopathological investigation. Brazilian Journal of Microbiology, 33(2), 174–177.

    Article  Google Scholar 

  • Delbem, A.C.B., Freire L.R., Silva C.A., Muller E.E., Dias R.A., Neto J.S.F. and Freitas J.C., 2004. Fatores de risco associados à soropositividade para leptospirose em matrizes suıínas. Ciência Rural, 34(3), 847–852.

    Article  Google Scholar 

  • Desvars, A., Cardinale, E. and Michault, A., 2011. Animal leptospirosis in small tropical areas. Epidemiology Infection, 139, 167–188.

    Article  CAS  PubMed  Google Scholar 

  • Ellis, W.A., 2015. Animal leptospirosis. Current Topics in Microbiology and Immunology, 387, 99–137.

    CAS  PubMed  Google Scholar 

  • Faine, S., Adler, B., Bolin, C. and Perolat, P., 1999. Leptospira and Leptospirosis, (MediSci, Melborne).

    Google Scholar 

  • Favero, A.C.M., Pinheiro S.R., Vasconcellos S.A., Morais Z.M., Ferreira F. and Ferreira Neto J.S., 2002. Most frequent serovars of leptospires in serological tests of buffaloes, sheep, goats, horses, swine and dogs from several Brazilian states. Ciência Rural, 32(4), 613–619.

    Article  Google Scholar 

  • Figueiredo, Í.L., Alves, C.J., Silva, L.C.A., Oliveira, R.M. and Azevedo, S.S., 2013. Leptospirose suína: uma importante causa de falhas e perdas reprodutivas. Revista Brasileira de Reprodução Animal, 37(4), 344-353.

    Google Scholar 

  • Fornazari, F., Da Silva, R.C., Richini-Pereira, V.B., Beserra, H.E., Luvizotto, M.C. and Langoni, H., 2012. Comparison of conventional PCR, quantitative PCR, bacteriological culture and the Warthin Starry technique to detect Leptospira spp. in kidney and liver samples from naturally infected sheep from Brazil. Journal of Microbiological Methods, 90(3), 321-326.

    Article  CAS  PubMed  Google Scholar 

  • Guerra, M.A., 2013. Leptospirosis: public health perspectives. Biologicals, 41(5), 295-297.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hamond, C., Martins, G., Loureiro, A.P., Pestana, C., Lawson-Ferreira, R., Medeiros, M.A. and Lilenbaum, W., 2014. Urinary PCR as an increasingly useful tool for an accurate diagnosis of leptospirosis in livestock. Veterinary Research Communications, 38(1), 81–85.

    Article  CAS  PubMed  Google Scholar 

  • Houwers, D.J., Goris, M.G., Abdoel, T., Kas, J.A., Knobbe, S.S., van Dongen, A.M., Westerduin, F.E., Klein, W.R. and Hartskeerl, R.A., 2011. Agglutinating antibodies against pathogenic Leptospira in healthy dogs and horses indicate common exposure and regular occurrence of subclinical infections. Veterinary Microbiology, 148(2-4), 449–451.

    Article  CAS  PubMed  Google Scholar 

  • Jorge, R.S.P., Ferreira, F., Neto, J.S.F., Vasconcellos, S.A., Lima, E.S., de Morais, Z.M. and de Souza, G.O., 2011. Exposure of free-ranging wild carnivores, horses and domestic dogs to Leptospira spp. in the northern Pantanal, Brazil. Memórias do Instituto Oswaldo Cruz, 106(4), 441-444.

    Article  PubMed  Google Scholar 

  • Kasimanickam, R., Whittier, W.D., Collins, J.C., Currin, J.F., Inman, B., Hall, J.B. and Pelzer, K.D., 2007. A field study of the effects of a monovalent Leptospira borgpetersenii serovar Hardjo strain Hardjobovis vaccine administered with oxytetracycline on reproductive performance in beef cattle. Journal of the American Veterinary Medical Association, 231(11), 1709-1714.

    Article  CAS  PubMed  Google Scholar 

  • Kikuti, M., Langoni, H., Nobrega, D.N., Corrêa, A.P.F.L. and Ullmann, L.S., 2012. Occurrence and risk factors associated with canine leptospirosis. Journal of Venomous Animals and Toxins Including Tropical Diseases, 18(1), 124-127.

    Article  Google Scholar 

  • Lau, C.L., Smythe, L.D., Craig, S.B. and Weinstein, P., 2010. Climate change, flooding, urbanization and leptospirosis: fuelling the fire? Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(10), 631-8.

    Article  PubMed  Google Scholar 

  • Lelu, M., Munoz-Zanzi, C., Higgins, B. and Galloway, R., 2015. Seroepidemiology of leptospirosis in dogs from rural and slum communities of Los Rios Region, Chile. BMC Veterinary Research, 11(1), 31.

    Article  PubMed  PubMed Central  Google Scholar 

  • Levett, P. N., 2004. Leptospirosis: A forgotten zoonosis? Clinical and Applied Immunology Reviews, 4(6), 435-448.

    Article  Google Scholar 

  • Martins, G. and Lilenbaum, W., 2013. The panorama of animal leptospirosis in Rio de Janeiro, Brazil, regarding the seroepidemiology of the infection in tropical regions. BMC Veterinary Research, 9, 237.

    Article  PubMed  PubMed Central  Google Scholar 

  • Miller, M.D., Annis, K.M., Lappin, M.R. and Lunn, K.F., 2011. Variability in results of the microscopic agglutination test in dogs with clinical leptospirosis and dogs vaccinated against leptospirosis. Journal of Veterinary Internal Medicine, 25(3), 426-432.

    Article  CAS  PubMed  Google Scholar 

  • Monahan, A.M., Callanan, J.J. and Nally, J.E., 2009. Review paper: Host-pathogen interactions in the kidney during chronic leptospirosis. Veterinary Pathology, 46(5), 792-799.

    Article  CAS  PubMed  Google Scholar 

  • Mughini-Gras, L., Bonfanti, L., Natale, A., Comin, A., Ferronato, A., La Greca, E., Patregnani, T., Lucchese, L. and Marangon, S., 2014. Application of an integrated outbreak management plan for the control of leptospirosis in dairy cattle herds. Epidemiology and Infection, 142(6), 1172-1181.

    Article  CAS  PubMed  Google Scholar 

  • Munoz-Zanzi, C., Mason, M., Encina, C., Gonzalez, M. and Berg, S., 2014. Household characteristics associated with rodent presence and Leptospira infection in rural and urban communities from southern Chile. The American Journal of Tropical Medicine and Hygiene, 90(3), 497–506.

    Article  PubMed  PubMed Central  Google Scholar 

  • OIE (2014) Leptospirosis, In: Manual of diagnostic tests and vaccines for terrestrial animals. World Organization for Animal Health, Paris.

  • Otaka, D.Y., Martins, G., Hamond, C., Penna, B., Medeiros, M.A. and Lilenbaum, W., 2012. Serology and PCR for bovine leptospirosis: herd and individual approaches. Veterinary Record, 170(13), 338–339.

    Article  CAS  PubMed  Google Scholar 

  • Picardeau, M., 2013. Diagnosis and epidemiology of leptospirosis. Médicine et Maladies Infectieuses, 43(1), 1–9.

    Article  CAS  Google Scholar 

  • Pinna, A.E., Martins, G. and Lilenbaum, W., 2012. Leptospirosis and embryo recovery rate in mares. Veterinary Record, 170(2), 60.

    Article  CAS  PubMed  Google Scholar 

  • Pinto, P.S., Loureiro, A.P., Penna, B. and Lilenbaum, W., 2015. Usage of Leptospira spp. local strains as antigens increases the sensitivity of the serodiagnosis of bovine leptospirosis. Acta Tropica, 149, 163-167.

    Article  CAS  PubMed  Google Scholar 

  • Rissi, D.R. and Brown, C.A., 2014. Diagnostic features in 10 naturally occurring cases of acute fatal canine leptospirosis. Journal of Veterinary Diagnostic Investigation, 26(6), 799-804.

    Article  PubMed  Google Scholar 

  • Roach, J.M., van Vuuren, M. and Picard, J.A., 2010. A serological survey of antibodies to Leptospira species in dogs in South Africa. Journal of the South African Veterinary Association, 81(3), 156–159.

    Article  CAS  PubMed  Google Scholar 

  • Roqueplo, C., Cabre, O., Davoust, B. and Kodjo, A., 2013. Epidemiological study of animal Leptospirosis in New Caledonia. Veterinary Medicine International, 81(2), 189-197.

    Google Scholar 

  • Sarmento, A.M.C., Azevedo, S.S., Morais, Z.M., Souza, G.O., Oliveira, F.C.S., Gonçales, A.P., Miraglia, F. and Vasconcellos, S.A., 2012. Use of Leptospira spp. strains isolated in Brazil in the microscopic agglutination test applied to diagnosis of leptospirosis in cattle herds in eight Brazilian states. Pesquisa Veterinária Brasileira, 32(7), 601-606.

    Article  Google Scholar 

  • Subharat, S., Wilson, P.R., Heuer, C. and Collins-Emerson, J.M., 2011. Vaccination for leptospirosis improved the weaning percentage of 2-year-old farmed red deer hinds in New Zealand. New Zealand Veterinary Journal, 59(4), 191-196.

    Article  CAS  PubMed  Google Scholar 

  • Suepaul, S.M., Carrington, C.V., Campbell, M., Borde, G. and Adesiyun, A.A., 2010. Serovars of Leptospira isolated from dogs and rodents. Epidemiology & Infection, 138(7), 1059-1070.

    Article  CAS  Google Scholar 

  • Suepaul, S.M., Carrington, C.V., Campbell, M., Borde, G. and Adesiyun A.A., 2011. Seroepidemiology of leptospirosis in livestock in Trinidad. Tropical Animal Health and Production, 43(2), 367–375.

    Article  PubMed  Google Scholar 

  • Sykes, J.E., Hartmann, K., Lunn, K.F., Moore, G.E., Stoddard, R.A. and Goldstein, R.E., 2011. Small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention. Journal of Veterinary Internal Medicine, 25(1), 1-13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Verma, A.K., Kumar, A., Dhama, K., Deb, R., Rahal, A., Mahima and Chakraborty, S., 2012. Leptospirosis - persistence of a dilemma: an overview with particular emphasis on trends and recent advances in vaccines and vaccination strategies. Pakistan Journal of Biological Sciences, 15, 954-963.

    Article  PubMed  Google Scholar 

  • WHO, 2010. Human leptospirosis: guidance for diagnosis, surveillance and control. World Health Organization.

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Acknowledgements

The authors are thankful to Dr. G. Martins and L. Correia (UFF) for their help during the selection and analysis of the papers. WL is a CNPq fellow, and PSP and HL are CAPES fellows.

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  1. Laboratory of Veterinary Bacteriology, Biomedical Institute, Fluminense Federal University, 101 Prof. Hernani Mello Street, Niterói, Rio de Janeiro, Brazil

    Priscila S. Pinto, Hugo Libonati & Walter Lilenbaum

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  1. Priscila S. Pinto
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  2. Hugo Libonati
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  3. Walter Lilenbaum
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Correspondence to Walter Lilenbaum.

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Pinto, P.S., Libonati, H. & Lilenbaum, W. A systematic review of leptospirosis on dogs, pigs, and horses in Latin America. Trop Anim Health Prod 49, 231–238 (2017). https://doi.org/10.1007/s11250-016-1201-8

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