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Evaluating the Electrochemical Detection of Methyldopa in the Presence of Hydrochlorothiazide Using a Modified Carbon Paste Electrode and Voltammetric Analysis

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Abstract

High blood pressure or hypertension, is a common condition in which the blood pressure against the walls of the arteries is higher than usual. This extra pressure may damage the arteries, heart, and other organs, resulting in serious health complications, including heart disease, stroke, kidney disease, and other vascular diseases. Therefore, the sensitive and accurate determination of antihypertensive drugs in pharmaceutical samples and biological fluids is very useful and effective for diagnostic and biomedical research. In the current study, the simultaneous voltammetric measurement of methyldopa and hydrochlorothiazide utilizing a carbon paste electrode that has been modified with a Co3O4/g-C3N4 nanocomposite and ionic liquid (Co3O4/g-C3N4/ILCPE). Utilizing the methods of differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometry (CHA), the electrochemical function of the Co3O4/g-C3N4/ILCPE sensor was examined. Electrochemical investigations revealed that the methyldopa oxidation current was boosted and moved to negative potentials on the modified electrode’s surface. The prepared sensor exhibited excellent peak current response towards methyldopa with a linear detection range of 1.0–800.0 µM and a low limit of detection (LOD) of 0.25 µM. The Co3O4/g-C3N4/ILCPE sensor sensitivity was approximately 0.0542 µA µM− 1. Furtheremore, the prepared sensor presented good repeatability, stability, and selectivity. This modified electrode worked satisfactorily as a sensor for methyldopa and hydrochlorothiazide detection in pharmaceutical samples.

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Authors and Affiliations

  1. Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran

    Saman Borji

  2. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Hadi Beitollahi & Fariba Garkani Nejad

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  1. Saman Borji
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Borji, S., Beitollahi, H. & Nejad, F.G. Evaluating the Electrochemical Detection of Methyldopa in the Presence of Hydrochlorothiazide Using a Modified Carbon Paste Electrode and Voltammetric Analysis. Top Catal 67, 773–784 (2024). https://doi.org/10.1007/s11244-023-01855-y

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