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Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine

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Abstract

The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO3·H2O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co2+ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN2O3 octahedron. The complex exhibits moderate antithrombolytic activity (38 % screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 %) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 %) was recorded against both Gram-positive and Gram-negative bacterial species.

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Authors and Affiliations

  1. Department of Chemistry, University of Agriculture, Faisalabad, 38040, Pakistan

    Muhammad Nadeem Akhtar & Javed Iqbal

  2. Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen, AB24 3UE, Scotland, UK

    William T. A. Harrison

  3. Department of Biochemistry, University of Agriculture, Faisalabad, 38040, Pakistan

    Muhammad Shahid

  4. Department of Chemistry, Government College University, Lahore, 54000, Pakistan

    Islam-Ullah Khan &  Ejaz

Authors
  1. Muhammad Nadeem Akhtar
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  2. William T. A. Harrison
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  3. Muhammad Shahid
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  4. Islam-Ullah Khan
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  5. Ejaz
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  6. Javed Iqbal
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Corresponding authors

Correspondence to Muhammad Nadeem Akhtar, William T. A. Harrison or Muhammad Shahid.

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Akhtar, M.N., Harrison, W.T.A., Shahid, M. et al. Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. Transition Met Chem 41, 325–330 (2016). https://doi.org/10.1007/s11243-016-0025-8

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  • DOI: https://doi.org/10.1007/s11243-016-0025-8

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