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Non-contrast-enhanced magnetic resonance imaging technique diagnoses DVT and classifies thrombus

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Abstract

The accuracy of non-contrast MRI in diagnosing acute deep vein thrombosis (DVT) of the lower extremities is different. To explore the application of high-resolution non-contrast 3D CUBE T1-weighted MRI in the lower extremities DVT. We recruited 26 patients suspected DVT of the lower extremities from Hebei General Hospital in China. All patients underwent high-resolution non-contrast 3D CUBE T1-weighted MRI. We evaluated the sensitivity, specificity, positive predictive value, and negative predictive value of diagnosing thrombosis. And we divided thrombi into two parts: filling thrombus (FT) and non-filling thrombus (NFT), compared the agreement between MRI and Ultrasound (US) and analysed the locations of thrombi. Compared with US, MRI yielded a sensitivity of 79%, a specificity of 94.2% in mean value, a sensitivity of 85.7%, 97.4%, and 51.7% in iliac, femoral-popliteal, and calf segments respectively, a specificity of 97.6%, 88.3%, and 98.2% in iliac, femoral-popliteal, and in calf segments respectively. The accuracy of MRI in the diagnosis of lower extremity DVT was in very good agreement (κ = 0.711, 95% CI 0.627, 0.795). The FT was the most part in US and CUBE (68/56), CUBE can detect more NFT in femoral vein than US (22/4). 3D CUBE T1-weighted MRI can be used to accurately diagnose acute DVT and detect more NFT. It has the potential of follow-up at the end of treatment to establish a new baseline to stop anticoagulant drug.

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Authors and Affiliations

  1. Department of Radiology, Hebei General Hospital, Shijiazhuang, Hebei, China

    Shanshan Shen, Yanqin Lan, Lei He & Yingmin Chen

  2. Department of Vascular Surgery, Hebei General Hospital, Shijiazhuang, Hebei, China

    Jikuan Li

  3. GE Healthcare, MR Research China, Beijing, China

    Min Li

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  1. Shanshan Shen
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  2. Yanqin Lan
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Correspondence to Shanshan Shen.

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Shen, S., Lan, Y., He, L. et al. Non-contrast-enhanced magnetic resonance imaging technique diagnoses DVT and classifies thrombus. J Thromb Thrombolysis 53, 663–670 (2022). https://doi.org/10.1007/s11239-021-02538-9

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