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Prothrombinase: the paradigm for membrane bound enzyme complexes; a memoir

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Abstract

This review is a brief summary of the history of the development of the Prothrombinase complex paradigm and its incorporation into the “extrinsic pathway”. It summarizes my laboratory’s research from 1968 to 2012 and identifies many of the key players in these efforts.

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References

  1. Mann KG, Batt CW (1969) The Molecular Weights of Bovine Thrombin and its Primary Autolysis Products. J Biol Chem 244:6555–6557

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  2. Mann KG, Heldebrant CM, Fass DN (1971) Multiple Active Forms of Thrombin. II. Mechanism of Production From Prothrombin. J. Biol. Chem. 246:6106–6114

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Reviews which contain numerous references to the work of other laboratories

  1. Mann KG, Kalafatis M (2003) Factor V: A combination of Dr. Jekyll and Mr Hyde Blood 1–1:1–11

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  2. Mann KG, Nesheim ME, Church WR, Haley P, Krishnaswamy S (1990) Surface-Dependent Reactions of the Vitamin K-dependent Enzyme Complexes. Blood 76:1–16

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  7. Hockin MF, Kalafatis M, Shatos M, Mann KG (1997) Protein C Activation and Factor Va Inactivation on Human Umbilical Vein Endothelial Cells. Arterioscler Thromb Vasc Biol 17:2765–2775

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  8. Campbell JE, Brummel-Ziedins KE, Butenas S, Mann KG (2010) Cellular regulation of blood coagulation: A model for venous stasis. Blood 116:6082–6091

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  9. Undas A, Brummel KE, Musial J, Mann KG, Szczeklik A (2001) Simvastatin Depresses Blood Clotting by Inhibiting Activation of Prothrombin, Factor V, and Factor XIII and by Enhancing Factor Va Inactivation. Circulation 103:2248–2253

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  10. Adams TE, Everse SJ, Mann KG (2003) Predicting the pharmacology of thrombin inhibitors. J Thromb Haemost 1:1024–1027

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Authors and Affiliations

  1. College of Medicine, University of Vermont, Burlington, VT, USA

    Kenneth G. Mann

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  1. Kenneth G. Mann
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Correspondence to Kenneth G. Mann.

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This review covers 44 years of research and over 400 publications from my laboratory. I do not have any conflict of interest, nor any of my family members, dealing with this research.

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Mann, K.G. Prothrombinase: the paradigm for membrane bound enzyme complexes; a memoir. J Thromb Thrombolysis 52, 379–382 (2021). https://doi.org/10.1007/s11239-021-02402-w

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  • DOI: https://doi.org/10.1007/s11239-021-02402-w

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