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Alterations of the thrombin generation profile in rheumatoid arthritis

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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder resulting in the erosion of the cartilage and bone. Systemic involvement including the cardiovascular system with the risk of atherosclerosis may also occur. Calibrated automated thrombogram (CAT), a commercially available thrombin generation assay is suitable for the general assessment of the functionality of coagulation system. In this study we performed CAT assay in RA patients and in non-affected control subjects (matched for age, sex and comorbidities). Among the CAT parameters Velocity Index increased (from 60 to 83 nM/min), Lag Time and Time to Peak decreased (from 3.47 to 2.83 min and from 6.98 to 5.58 min respectively) in RA. On the other hand, Endogenous Thrombin Potential values decreased (from 1242 to 1108 nM min). The observed alterations were not associated with the applied therapy. These results indicate that the velocity of thrombin formation is increased, while the thrombin generating capability is reduced in RA.

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Abbreviations

aPTT:

Activated partial thromboplastin time

CAT:

Calibrated Automated Thrombogram

CRP:

C reactive protein

DAS:

Disease activity score

DMARD:

Disease modifying anti-rheumatic drugs

ESR:

Erythrocyte sedimentation rate

ETP:

Endogenous thrombin potential

NSAID:

Non-steroidal anti-inflammatory drugs

PT:

Prothrombin time

RA:

Rheumatoid arthritis

RF:

Rheumatoid factor

TG:

Thrombin generation

TT:

Thrombin time

v index:

Velocity Index

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Authors and Affiliations

  1. Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary

    Anita Kern, Eszter Barabás & Barna Vásárhelyi

  2. Diagon Ltd., Baross utca 48-52, 1047, Budapest, Hungary

    Anita Kern & Mária Kiszelák

  3. Department of Rheumatology, Faculty of Medicine, Albert Szent-Györgyi Health Center, University of Szeged, Kálvária sgt. 57, 6725, Szeged, Hungary

    Attila Balog & Sonja Dulic

Authors
  1. Anita Kern
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  2. Attila Balog
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  3. Sonja Dulic
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  4. Eszter Barabás
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  5. Mária Kiszelák
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  6. Barna Vásárhelyi
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Correspondence to Anita Kern.

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Kern, A., Balog, A., Dulic, S. et al. Alterations of the thrombin generation profile in rheumatoid arthritis. J Thromb Thrombolysis 41, 359–364 (2016). https://doi.org/10.1007/s11239-015-1251-1

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  • DOI: https://doi.org/10.1007/s11239-015-1251-1

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