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New method for the synthesis of 4-spirocyclopentane- and 4-spirocyclohexanenicotinic acid nitriles and amides

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Russian Chemical Bulletin Aims and scope

Abstract

The multicomponent condensation of cyclopentylidene- or cyclohexylidenemalononitrile, cyanoacetic acid amides or thioamides, and alkylating agents affords 4-spirocyclopentane- and 4-spirocyclohexanenicotinic acid nitriles and amides. The structures of several reaction products were determined by X-ray diffraction.

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Authors and Affiliations

  1. Lugansk State Pedagogical University, 2 ul. Oboronnaya, 91011, Lugansk, Ukraine

    I. V. Dyachenko & V. D. Dyachenko

  2. National Research Center “Kurchatov Institute”, 1 ul. Akad. Kurchatova, 123182, Moscow, Russian Federation

    P. V. Dorovatovskii

  3. Peoples’ Friendship University of Russia (RUDN University), 6 ul. Miklukho-Maklaya, 117198, Moscow, Russian Federation

    V. N. Khrustalev

  4. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    V. N. Khrustalev

  5. Lomonosov Moscow State University, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    V. G. Nenajdenko

Authors
  1. I. V. Dyachenko
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  2. V. D. Dyachenko
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  3. P. V. Dorovatovskii
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  4. V. N. Khrustalev
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  5. V. G. Nenajdenko
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Corresponding authors

Correspondence to I. V. Dyachenko, P. V. Dorovatovskii, V. N. Khrustalev or V. G. Nenajdenko.

Additional information

Dedicated to Academician of the Russian Academy of Sciences V. N. Charushin on the occasion of his 70th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 949–959, May, 2021.

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Project No. 075-03-2020-223 (FSSF-2020-0017)).

No human or animal subjects were involved in this research.

The authors declare no conflict of interest, financial or otherwise.

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Dyachenko, I.V., Dyachenko, V.D., Dorovatovskii, P.V. et al. New method for the synthesis of 4-spirocyclopentane- and 4-spirocyclohexanenicotinic acid nitriles and amides. Russ Chem Bull 70, 949–959 (2021). https://doi.org/10.1007/s11172-021-3172-9

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  • DOI: https://doi.org/10.1007/s11172-021-3172-9

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