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Synthesis and study of new 2H-pyranoquinolin-2-one-based inhibitors of blood coagulation factors Xa and XIa

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Russian Chemical Bulletin Aims and scope

Abstract

Condensation of 7-hydroxy-1,2,2,4-tetramethylhydroquinoline-6-carbaldehydes with various hetaryl-substituted 3-oxo esters afforded a series of hybrid hydro-6,8,8,9-tetramethyl-2H-pyrano[3,2-g]quinolin-2-ones. A number of these compounds exhibited relatively high inhibitory activity against blood coagulation factors Xa and XIa.

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Authors and Affiliations

  1. Voronezh State University, 1 Universitetskaya pl., 394018, Voronezh, Russian Federation

    A. Yu. Potapov, V. A. Polikarchuk, I. V. Ledenyova, N. V. Stolpovskaya & Kh. S. Shikhaliev

  2. Belgorod State National Research University, 85 ul. Pobedy, 308015, Belgorod, Russian Federation

    B. V. Paponov

  3. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 30 ul. Srednyaya Kalitnikovskaya, 109029, Moscow, Russian Federation

    N. A. Podoplelova & M. A. Panteleev

  4. Research Institute of Applied Acoustics, 7A ul. 9 Maya, 141980, Dubna, Moscow Region, Russian Federation

    D. V. Kryl’skii

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  1. A. Yu. Potapov
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  2. B. V. Paponov
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  3. N. A. Podoplelova
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  4. M. A. Panteleev
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  5. V. A. Polikarchuk
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  6. I. V. Ledenyova
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  9. Kh. S. Shikhaliev
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Correspondence to A. Yu. Potapov.

Additional information

This work was financially supported by the Russian Science Foundation (Project No. 18-74-10097).

This work does not involve human participants and animal subjects.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 492–497, March, 2021.

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Potapov, A.Y., Paponov, B.V., Podoplelova, N.A. et al. Synthesis and study of new 2H-pyranoquinolin-2-one-based inhibitors of blood coagulation factors Xa and XIa. Russ Chem Bull 70, 492–497 (2021). https://doi.org/10.1007/s11172-021-3114-6

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  • DOI: https://doi.org/10.1007/s11172-021-3114-6

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