Abstract
New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds.
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References
A. B. Oliveira, M. F. Dolabela, F. C. Braga, R. L. R. P. Jácome, F. P. Varotti, M. M. Póvoa, An. Acad. Bras. Cienc., 2009, 81, 715.
T. N. Kudryavtseva, A. Yu. Lamanov, L. G. Klimova, G. V. Nazarov, Russ. Chem. Bull., 2017, 66, 123.
S. S. Bobylev, K. I. Kobrakov, D. N. Kuznetsov, A. G. Ruchkina, S. A. Shevelev, A. Kh. Shakhnes, A. N. Fakhrutdinov, Russ. Chem. Bull., 2015, 64, 154.
S. S. Bobylev, D. N. Kuznetsov, K. I. Kobrakov, A. G. Ruchkina, A. N. Fakhrutdinov, Russ. J. Org. Chem., 2015, 51, 1572.
M.-G. A. Shvekhgeymer, O. A. Moreva, Dokl. Akad. Nauk, 2000, 372, 778
M.-G. A. Shvekhgeymer, O. A. Moreva, [Dokl. Chem. (Engl. Transl.), 2000, 382].
Molinspiration Cheminformatics Slovak Republic, URL: http://www.molinspiration.com/cgi-bin/properties (date of application 19.05.2017).
C. A. Lipinski, F. Lombardo, B. W. Dominy, P. Feeney, Adv. Drug. Deliv. Rev., 1997, 23, 3.
Institute of Biomedical Chemistry, URL: http://www.pharmaexpert.ru/PASSOnline/(date of application 21.02.2015).
Institute of Biomedical Chemistry.–URL: http://www.way2drug.com/gusar/acutoxpredict.html (date of application 19.05.2017).
A. V. El’tsov, Laboratornyi praktikum po sintezu promezhutochnykh produktov i krasitelei. Uchebnoe posobie dlya vuzov [Laboratory Manual on the Synthesis of Intermediate Products and Dyes. Textbook for High Schools], Khimiya, Leningrad, 1985, 352 pp. (in Russian).
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 0878–0883, May, 2018.
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Melyshenkova, V.V., Kuznetsov, D.N., Ruchkina, A.G. et al. Synthesis of new acridine-9-carboxylic acid derivatives. Russ Chem Bull 67, 878–883 (2018). https://doi.org/10.1007/s11172-018-2152-1
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DOI: https://doi.org/10.1007/s11172-018-2152-1