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3-Pyridylisoxazoles as prototypes of antiaggregatory agents

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Abstract

A series of 5-alkyl-3-pyridylisoxazoles was synthesized using the 3-(3-pyridyl)isoxazole scaff old. All compounds of the series possessed antiaggregatory activity in the concentration range of 6•10–6–6•10–4 mol L–1. Analysis of the experimental data on the antiaggregatory activity revealed the presence of spatial constraints for the alkyl substituents in position 5 of the isoxazole ring. 5-Alkyl-3-(3-pyridyl)isoxazoles are rather selective for platelet membrane receptors.

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Authors and Affiliations

  1. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosigina, 119334, Moscow, Russian Federation

    O. V. Demina, N. E. Belikov, S. D. Varfolomeev & A. A. Khodonov

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  1. O. V. Demina
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  2. N. E. Belikov
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  3. S. D. Varfolomeev
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  4. A. A. Khodonov
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Correspondence to O. V. Demina.

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Based on the materials of the III Interdisciplinary Symposium on Medicinal, Organic, and Biological Chemistry and Pharmaceutics (MOBI-ChemPharma-2017; May 28—31, 2017; Sevastopol, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 0866–0877, May, 2018.

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Demina, O.V., Belikov, N.E., Varfolomeev, S.D. et al. 3-Pyridylisoxazoles as prototypes of antiaggregatory agents. Russ Chem Bull 67, 866–877 (2018). https://doi.org/10.1007/s11172-018-2151-2

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  • DOI: https://doi.org/10.1007/s11172-018-2151-2

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