Abstract
The effect of a spatially-hindered phenol, namely sodium 1-N-acetylamino-1-carboxy-2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, on the functionality of mitochondria of rat liver was studied. Stress impact caused a 3 to 4-fold increase in the fluorescence intensity of the products of lipid peroxidation (LPO) in the membranes of these organelles. The preparation reduced the intensity of LPO to the control level, which was conductive to maintaining high functional activity of the mitochondria. Prevention of mitochondrial dysfunction was probably associated with an increase in the resistance of animals to stress factors.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0721–0725, April, 2018.
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Zhigacheva, I.V., Rasulov, M.M. Antistress properties of sodium 1-N-acetylamino-1-carboxy-2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate. Russ Chem Bull 67, 721–725 (2018). https://doi.org/10.1007/s11172-018-2128-1
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DOI: https://doi.org/10.1007/s11172-018-2128-1