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The Grandberg reaction in the synthesis of biologically active compounds

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Abstract

The review is focused on the Grandberg synthesis, namely, the synthesis of tryptamines from arylhydrazines and γ-halocarbonyl compounds, as an exceptionally useful and efficient methodology to access biologically active indole heterocycles.

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Authors and Affiliations

  1. Russian State Agrarian University–Moscow Timiryazev Agricultural Academy, 49 ul. Timiryazevskaya, Moscow, 119991, Russian Federation

    N. M. Przheval’skii, R. K. Laipanov, G. P. Tokmakov & N. L. Nam

Authors
  1. N. M. Przheval’skii
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  2. R. K. Laipanov
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  3. G. P. Tokmakov
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  4. N. L. Nam
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Corresponding author

Correspondence to N. M. Przheval’skii.

Additional information

Based on the materials of the International Congress on the Heterocyclic Chemistry “KOST-2015” (October 18–23, 2015, Moscow, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1709–1715, July, 2016.

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Przheval’skii, N.M., Laipanov, R.K., Tokmakov, G.P. et al. The Grandberg reaction in the synthesis of biologically active compounds. Russ Chem Bull 65, 1709–1715 (2016). https://doi.org/10.1007/s11172-016-1499-4

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  • DOI: https://doi.org/10.1007/s11172-016-1499-4

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