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Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine

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Abstract

Methods for the synthesis of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine were developed. Some of obtained compounds possess high antibacterial and antitumor activity in vitro.

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Authors and Affiliations

  1. Education and Research Center of Pharmacy, Kazan (Volga Region) Federal University, 18 ul. Kremlevskaya, 420008, Kazan, Russian Federation

    N. V. Shtyrlin, R. M. Vafina, M. V. Pugachev, R. M. Khaziev, E. V. Nikitina, M. I. Zeldi, A. G. Iksanova & Yu. G. Shtyrlin

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  1. N. V. Shtyrlin
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  2. R. M. Vafina
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  3. M. V. Pugachev
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  4. R. M. Khaziev
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  5. E. V. Nikitina
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  6. M. I. Zeldi
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  7. A. G. Iksanova
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  8. Yu. G. Shtyrlin
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Correspondence to Yu. G. Shtyrlin.

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Dedicated to Academician of the Russian Academy of Sciences N. S. Zefirov on the occasion of his 80th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0537—0545, February, 2016.

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Shtyrlin, N.V., Vafina, R.M., Pugachev, M.V. et al. Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine. Russ Chem Bull 65, 537–545 (2016). https://doi.org/10.1007/s11172-016-1334-y

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  • DOI: https://doi.org/10.1007/s11172-016-1334-y

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