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Trekrezan as a stimulator of muscle strength and endurance. Possible molecular mechanisms of action

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Abstract

Trekrezan activated the in vivo expression of the PGC-1α gene in rat muscle tissues. Quantification of mitochondria in tissues and gene expression analysis for genes involved in regulatory energy metabolism cascades revealed that the mechanisms of the energy metabolism regulation are probably coupled with protein biosynthesis as well as with innate immunity. The immunostimulatory and adaptogenic drug trekrezan was found to induce concerted in vivo stimulation of the expression of the gene coding tryptophanyl-tRNA synthetase and its activity in the expression of the PGC-1α gene.

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Authors and Affiliations

  1. State Research Institute of Chemistry and Chemical Technology of Organoelement Compounds, 38 sh. Entuziastov, 105118, Moscow, Russian Federation

    M. M. Rasulov & R. M. Rasulov

  2. Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 ul. Favorskogo, 664033, Irkutsk, Russian Federation

    K. A. Abzaeva & M. G. Voronkov

  3. Penza State Technological University, 1a pr. Baydukova, 440039, Penza, Russian Federation

    M. I. Yakhkind

  4. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119334, Moscow, Russian Federation

    I. V. Zhigacheva & I. S. Nikolaeva

Authors
  1. M. M. Rasulov
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  2. K. A. Abzaeva
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  3. M. I. Yakhkind
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  4. I. V. Zhigacheva
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  5. I. S. Nikolaeva
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  6. R. M. Rasulov
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  7. M. G. Voronkov
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Corresponding author

Correspondence to M. M. Rasulov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1682–1685, July, 2015.

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Rasulov, M.M., Abzaeva, K.A., Yakhkind, M.I. et al. Trekrezan as a stimulator of muscle strength and endurance. Possible molecular mechanisms of action. Russ Chem Bull 64, 1682–1685 (2015). https://doi.org/10.1007/s11172-015-1060-x

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  • DOI: https://doi.org/10.1007/s11172-015-1060-x

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